N-{(1Z)-[2-(chloromethyl)-2,3-dihydro[1,3]oxazolo[3,2-a]indol-9-yl]methylene}-N'-(4-methylphenyl)sulfamide

Base Information

Chemical Name:N-{(1Z)-[2-(chloromethyl)-2,3-dihydro[1,3]oxazolo[3,2-a]indol-9-yl]methylene}-N'-(4-methylphenyl)sulfamide
CAS No.:1342804-72-1
Molecular Formula:C₁₉H₁₈ClN₃O₃S
Molecular Weight:403.889
Hs Code.:

Synonyms:N-{(1Z)-[2-(chloromethyl)-2,3-dihydro[1,3]oxazolo[3,2-a]indol-9-yl]methylene}-N'-(4-methylphenyl)sulfamide

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Chemical Property of N-{(1Z)-[2-(chloromethyl)-2,3-dihydro[1,3]oxazolo[3,2-a]indol-9-yl]methylene}-N'-(4-methylphenyl)sulfamide

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Technology Process of N-{(1Z)-[2-(chloromethyl)-2,3-dihydro[1,3]oxazolo[3,2-a]indol-9-yl]methylene}-N'-(4-methylphenyl)sulfamide

There total 3 articles about N-{(1Z)-[2-(chloromethyl)-2,3-dihydro[1,3]oxazolo[3,2-a]indol-9-yl]methylene}-N'-(4-methylphenyl)sulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1342804-70-9
{(1Z)-[2-(chloromethyl)-2,3-dihydro[1,3]oxazolo[3,2-a]indol-9-yl]methylene}sulfamoyl chloride

: 106-49-0,12221-03-3
p-toluidine

: 1342804-72-1
N-{(1Z)-[2-(chloromethyl)-2,3-dihydro[1,3]oxazolo[3,2-a]indol-9-yl]methylene}-N'-(4-methylphenyl)sulfamide

Guidance literature:: With triethylamine; In acetonitrile;
DOI:10.1016/j.tet.2011.09.015

Reference yield:

: 5059-30-3
2-chloroindole-3-carboxaldehyde

: 1342804-72-1
N-{(1Z)-[2-(chloromethyl)-2,3-dihydro[1,3]oxazolo[3,2-a]indol-9-yl]methylene}-N'-(4-methylphenyl)sulfamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water; N,N-dimethyl-formamide / 1 h

1.2: 50 °C

2.1: isocyanate de chlorosulfonyle / benzene / 20 °C

3.1: triethylamine / acetonitrile

With isocyanate de chlorosulfonyle; triethylamine; sodium hydroxide; In water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/j.tet.2011.09.015

Reference yield:

: 1342804-65-2
2-(chloromethyl)-2,3-dihydro[1,3]oxazolo[3,2-a]indole-9-carbaldehyde

: 1342804-72-1
N-{(1Z)-[2-(chloromethyl)-2,3-dihydro[1,3]oxazolo[3,2-a]indol-9-yl]methylene}-N'-(4-methylphenyl)sulfamide

Guidance literature:: Multi-step reaction with 2 steps

1: isocyanate de chlorosulfonyle / benzene / 20 °C

2: triethylamine / acetonitrile

With isocyanate de chlorosulfonyle; triethylamine; In acetonitrile; benzene;
DOI:10.1016/j.tet.2011.09.015