2'-Deoxy-5'-O-DMT-N6-phenoxyacetyl-D-adenosine

Base Information

• Chemical Name: 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyl-D-adenosine
• CAS No.: 110522-82-2
• Molecular Formula: C39H37 N5 O7
• Molecular Weight: 687.752
• Mol file: 110522-82-2.mol

Synonyms:Adenosine,5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(phenoxyacetyl)- (9CI)

Chemical Property of 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyl-D-adenosine

Chemical Property:

• PSA: 139.08000
• LogP: 5.59110

Purity/Quality:

97% ^*data from raw suppliers

2''-Deoxy-5''-O-(4,4''-dimethoxytrityl)-N6-Phenoxyacetyladenosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2''-Deoxy-5''-O-(4,4''-dimethoxytrityl)-N6-phenoxyacetyladenosine is an adenosine (A280400) derivative used in the preparation of synthetic DNA, such as membrane-?insertable amphiphilic DNA.

Technology Process of 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyl-D-adenosine

There total 3 articles about 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyl-D-adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Phenoxy-acetic acid (2R,3S,5R)-2-(2-phenoxy-acetoxymethyl)-5-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester (110522-79-7) → N6-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine (110522-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine, water, pyridine

With pyridine; water; triethylamine;

DOI:10.1016/S0040-4039(00)95646-6

Reference yield:

2'-deoxy-D-adenosine (958-09-8,7005-15-4) → N6-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine (110522-82-2)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: triethylamine, water, pyridine

With pyridine; water; triethylamine;

DOI:10.1016/S0040-4039(00)95646-6

Reference yield:

N6-(phenoxyacetyl)-2'-deoxyadenosine (110522-74-2) → N6-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine (110522-82-2)

Guidance literature:

DOI:10.1016/S0040-4039(00)95646-6

upstream raw materials:

N⁶-(phenoxyacetyl)-2'-deoxyadenosine

Phenoxy-acetic acid (2R,3S,5R)-2-(2-phenoxy-acetoxymethyl)-5-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester

2'-deoxy-D-adenosine

Downstream raw materials:

Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine

Refernces