(S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(10-methoxy-anthracen-9-yl)-pentanoic acid

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Chemical Name:(S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(10-methoxy-anthracen-9-yl)-pentanoic acid
CAS No.:198275-45-5
Molecular Formula:C₃₇H₄₃N₃O₇Se
Molecular Weight:720.724
Hs Code.:

Synonyms:(S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(10-methoxy-anthracen-9-yl)-pentanoic acid

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Chemical Property of (S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(10-methoxy-anthracen-9-yl)-pentanoic acid

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Technology Process of (S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(10-methoxy-anthracen-9-yl)-pentanoic acid

There total 20 articles about (S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(10-methoxy-anthracen-9-yl)-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 198275-44-4
(S)-2-{(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(10-methoxy-anthracen-9-yl)-pentanoic acid

: 198275-45-5
(S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(10-methoxy-anthracen-9-yl)-pentanoic acid

Guidance literature:: With trifluoroacetic acid;
DOI:10.1055/s-1997-5792

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 198275-45-5
(S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(10-methoxy-anthracen-9-yl)-pentanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / Et₃N / dimethylformamide

2: 93 percent / DCC, DMAP / CH₂Cl₂ / 0 °C

3: 94 percent / H₂ / 10percent Pd/C / methanol; H₂O

4: 72 percent / DCC, 1-hydroxybenzotriazole (HOBt), N-methylmorpholine (NMM) / tetrahydrofuran

5: 98 percent / 1M TMSCl, 1M PhOH / CH₂Cl₂

6: 80 percent / H₂ / 10percent Pd/C / methanol; H₂O

7: 70 percent / 1.) 1-hydroxysuccinimide (HOSu), DCC; 2.) Et₃N / tetrahydrofuran

8: 80 percent / TFA

With 4-methyl-morpholine; dmap; 1-hydroxy-pyrrolidine-2,5-dione; chloro-trimethyl-silane; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; phenol; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1055/s-1997-5792

Reference yield:

: 60008-24-4
Boc-L-Ala-L-Hmb-OH

: 198275-45-5
(S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenylselanyl-propionylamino)-propionyloxy]-3-methyl-butyrylamino}-5-(10-methoxy-anthracen-9-yl)-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / DCC, 1-hydroxybenzotriazole (HOBt), N-methylmorpholine (NMM) / tetrahydrofuran

2: 98 percent / 1M TMSCl, 1M PhOH / CH₂Cl₂

3: 80 percent / H₂ / 10percent Pd/C / methanol; H₂O

4: 70 percent / 1.) 1-hydroxysuccinimide (HOSu), DCC; 2.) Et₃N / tetrahydrofuran

5: 80 percent / TFA

With 4-methyl-morpholine; 1-hydroxy-pyrrolidine-2,5-dione; chloro-trimethyl-silane; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; phenol; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1055/s-1997-5792