C₁₈H₁₄O₅

Base Information

• Chemical Name: C₁₈H₁₄O₅
• CAS No.: 247030-09-7
• Molecular Formula: C₁₈H₁₄O₅
• Molecular Weight: 310.306
• Mol file: 247030-09-7.mol

Synonyms:C₁₈H₁₄O₅

Chemical Property of C₁₈H₁₄O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₄O₅

There total 5 articles about C₁₈H₁₄O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

C17H16O4 (1400990-31-9) → C18H14O5 (247030-09-7)

Guidance literature:

With sodium hydride; In mineral oil; at 0 - 100 ℃; for 4h;

DOI:10.1021/jo301513x DOI:10.1021/jo301513x

Reference yield: 30.0%

(R)-2-(3-(4-hydroxy-2-oxo-2H-chromen-3-yl)-3-phenylpropanoyl)pyridine-1-oxide (1400990-16-0) → C17H16O4 (1400990-31-9) + C18H14O5 (247030-09-7)

Guidance literature:

With potassium hydroxide; In water; for 1h; Reflux;

DOI:10.1021/jo301513x DOI:10.1021/jo301513x

Reference yield:

(E)-2-(3-phenylprop-2-enoyl)pyridine-1-oxide (942129-14-8) → C18H14O5 (247030-09-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,6-bis<5',5'-diphenyl-4'-(S)-isopropyl oxazolin-2'-yl>pyridine; zinc trifluoromethanesulfonate / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: potassium hydroxide / water / 1 h / Reflux

With zinc trifluoromethanesulfonate; 2,6-bis<5',5'-diphenyl-4'-(S)-isopropyl oxazolin-2'-yl>pyridine; potassium hydroxide; In dichloromethane; water; 1: |Michael Addition;

DOI:10.1021/jo301513x DOI:10.1021/jo301513x

upstream raw materials:

C₁₇H₁₆O₄

(E)-2-(3-phenylprop-2-enoyl)pyridine-1-oxide

4-hydroxy[1]benzopyran-2-one

(R)-2-(3-(4-hydroxy-2-oxo-2H-chromen-3-yl)-3-phenylpropanoyl)pyridine-1-oxide

Downstream raw materials:

R-warfarin

Refernces

• 1、 Ray, Sumit K.,Singh, Pradeep K.,Molleti, Nagaraju,Singh, Vinod K.. "Enantioselective synthesis of coumarin derivatives by PYBOX-DIPH-Zn(II) complex catalyzed Michael reaction". . p. 8802 - 8808. Retrieved 2013/01/15.