Technology Process of (S)-(-)-3-N-methylamino-2-phenylpropan-1-ol
There total 7 articles about (S)-(-)-3-N-methylamino-2-phenylpropan-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 5 h / Ambient temperature; porcine pancreas lipase (PPL)
2: 77 percent / NEt3 / CH2Cl2 / 2 h / 0 °C
3: 80 percent / NaN3, tri-n-octylmethylammonium chloride / H2O / 6 h / 80 °C
4: LiAlH4 / tetrahydrofuran / 3 h / Heating
5: 90 percent / 2 M NaOH / H2O / 1) 0 deg C, 2 h, 2) r.t., 1 h
6: 80 percent / LiAlH4 / diethyl ether / 10 h / Heating
With
sodium hydroxide; lithium aluminium tetrahydride; sodium azide; Aliquat 336; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4020(01)80959-5
- Guidance literature:
-
Multi-step reaction with 6 steps
1: Ambient temperature; porcine pancreas lipase (PPL), phosphate buffer pH 7 (kept constant with 1 N NaOH)
2: 77 percent / NEt3 / CH2Cl2 / 2 h / 0 °C
3: 80 percent / NaN3, tri-n-octylmethylammonium chloride / H2O / 6 h / 80 °C
4: LiAlH4 / tetrahydrofuran / 3 h / Heating
5: 90 percent / 2 M NaOH / H2O / 1) 0 deg C, 2 h, 2) r.t., 1 h
6: 80 percent / LiAlH4 / diethyl ether / 10 h / Heating
With
sodium hydroxide; lithium aluminium tetrahydride; sodium azide; Aliquat 336; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4020(01)80959-5
