tert-butyl (S)-4-((R)-1-(benzyloxy)but-3-en-1-yl)-2,2-dimethyloxazolidine-3-carboxylate

Base Information

• Chemical Name: tert-butyl (S)-4-((R)-1-(benzyloxy)but-3-en-1-yl)-2,2-dimethyloxazolidine-3-carboxylate
• CAS No.: 1301261-31-3
• Molecular Formula: C₂₁H₃₁NO₄
• Molecular Weight: 361.481
• Mol file: 1301261-31-3.mol

Synonyms:tert-butyl (S)-4-((R)-1-(benzyloxy)but-3-en-1-yl)-2,2-dimethyloxazolidine-3-carboxylate

Chemical Property of tert-butyl (S)-4-((R)-1-(benzyloxy)but-3-en-1-yl)-2,2-dimethyloxazolidine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (S)-4-((R)-1-(benzyloxy)but-3-en-1-yl)-2,2-dimethyloxazolidine-3-carboxylate

There total 3 articles about tert-butyl (S)-4-((R)-1-(benzyloxy)but-3-en-1-yl)-2,2-dimethyloxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (102308-32-7) → tert-butyl (S)-4-((R)-1-(benzyloxy)but-3-en-1-yl)-2,2-dimethyloxazolidine-3-carboxylate (1301261-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: indium; ammonium chloride / tetrahydrofuran; water / 3 h

2: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 24 h / 20 °C

With indium; tetra-(n-butyl)ammonium iodide; sodium hydride; ammonium chloride; In tetrahydrofuran; water;

DOI:10.1055/s-0030-1258418

Reference yield:

C20H39NO4Si (1301261-30-2) → tert-butyl (S)-4-((R)-1-(benzyloxy)but-3-en-1-yl)-2,2-dimethyloxazolidine-3-carboxylate (1301261-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

2: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 24 h / 20 °C

With tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran;

DOI:10.1055/s-0030-1258418

Reference yield:

tert-butyl (R)-4-[(R)-1-hydroxybut-3-enyl]-2,2-dimethyloxazolidine-3-carboxylate (220317-59-9) → tert-butyl (S)-4-((R)-1-(benzyloxy)but-3-en-1-yl)-2,2-dimethyloxazolidine-3-carboxylate (1301261-31-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-imidazole / dichloromethane / 24 h

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

3: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 24 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-0030-1258418

upstream raw materials:

C₂₀H₃₉NO₄Si

(4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

tert-butyl (R)-4-[(R)-1-hydroxybut-3-enyl]-2,2-dimethyloxazolidine-3-carboxylate

Downstream raw materials:

C₂₁H₃₃NO₅

C₂₂H₃₅NO₇S

C₁₉H₃₁NO₇S

C₂₅H₄₅NO₇SSi