<(5S)-5-p-nitrobenzyloxycarbonyl-5-p-nitrobenzyloxycarbonylamino>-2-oxapentanoyl-S-benzyl-(2R)-cysteinyl-(2R)-valine p-nitrobenzyl ester

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Chemical Name:<(5S)-5-p-nitrobenzyloxycarbonyl-5-p-nitrobenzyloxycarbonylamino>-2-oxapentanoyl-S-benzyl-(2R)-cysteinyl-(2R)-valine p-nitrobenzyl ester
CAS No.:126166-98-1
Molecular Formula:C₄₂H₄₄N₆O₁₅S
Molecular Weight:904.909
Hs Code.:

Synonyms:<(5S)-5-p-nitrobenzyloxycarbonyl-5-p-nitrobenzyloxycarbonylamino>-2-oxapentanoyl-S-benzyl-(2R)-cysteinyl-(2R)-valine p-nitrobenzyl ester

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Chemical Property of <(5S)-5-p-nitrobenzyloxycarbonyl-5-p-nitrobenzyloxycarbonylamino>-2-oxapentanoyl-S-benzyl-(2R)-cysteinyl-(2R)-valine p-nitrobenzyl ester

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Technology Process of <(5S)-5-p-nitrobenzyloxycarbonyl-5-p-nitrobenzyloxycarbonylamino>-2-oxapentanoyl-S-benzyl-(2R)-cysteinyl-(2R)-valine p-nitrobenzyl ester

There total 7 articles about <(5S)-5-p-nitrobenzyloxycarbonyl-5-p-nitrobenzyloxycarbonylamino>-2-oxapentanoyl-S-benzyl-(2R)-cysteinyl-(2R)-valine p-nitrobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 126166-93-6
S-benzyl-(2R)-cysteinyl-(2R)-valine p-nitrobenzyl ester

: 126166-97-0
N-p-nitrobenzyloxycarbonyl-O-carbonylimidazole-(2S)-homoserine p-nitrobenzyl ester

: 126166-99-2
(S)-2-Oxo-[1,3]oxazinane-3,4-dicarboxylic acid bis-(4-nitro-benzyl) ester

: 126166-98-1
<(5S)-5-p-nitrobenzyloxycarbonyl-5-p-nitrobenzyloxycarbonylamino>-2-oxapentanoyl-S-benzyl-(2R)-cysteinyl-(2R)-valine p-nitrobenzyl ester

Guidance literature:: With dmap; In acetonitrile; at 40 - 45 ℃; for 48h; Yield given;
DOI:10.1016/S0040-4020(01)80113-7

Reference yield:

: 3257-18-9
benzyloxycarbonyl-S-benzylcysteine

: 126166-98-1
<(5S)-5-p-nitrobenzyloxycarbonyl-5-p-nitrobenzyloxycarbonylamino>-2-oxapentanoyl-S-benzyl-(2R)-cysteinyl-(2R)-valine p-nitrobenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / EEDQ / CH₂Cl₂ / 24 h / Ambient temperature

2: 87 percent / 48percent HBr / acetic acid; CH₂Cl₂ / 1 h / 10 °C

3: 70 percent / dimethylaminopyridine / acetonitrile / 48 h / 40 - 45 °C

With dmap; hydrogen bromide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; acetic acid; acetonitrile;
DOI:10.1016/S0040-4020(01)80113-7

Reference yield:

: 95307-20-3
(2R)-valine-p-nitrobenzyl ester

: 126166-98-1
<(5S)-5-p-nitrobenzyloxycarbonyl-5-p-nitrobenzyloxycarbonylamino>-2-oxapentanoyl-S-benzyl-(2R)-cysteinyl-(2R)-valine p-nitrobenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / EEDQ / CH₂Cl₂ / 24 h / Ambient temperature

2: 87 percent / 48percent HBr / acetic acid; CH₂Cl₂ / 1 h / 10 °C

3: 70 percent / dimethylaminopyridine / acetonitrile / 48 h / 40 - 45 °C

With dmap; hydrogen bromide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; acetic acid; acetonitrile;
DOI:10.1016/S0040-4020(01)80113-7