(2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]dioxolan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine

Base Information

Chemical Name:(2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]dioxolan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine
CAS No.:335381-88-9
Molecular Formula:C₂₂H₂₃N₅O₆
Molecular Weight:453.455
Hs Code.:

Synonyms:(2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]dioxolan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]dioxolan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine

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Technology Process of (2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]dioxolan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine

There total 11 articles about (2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]dioxolan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 335381-88-9
(2S,3S,4R)-N-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]dioxolan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine

Guidance literature:

Reference yield: 85.0%

: 335381-88-9
(2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]dioxolan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine

Guidance literature:

Reference yield:

: 335382-02-0
(2S)-2-methyl-2-dimethoxymethyl-6-nitro-2H-1-benzopyran

: 335381-88-9
(2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]dioxolan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine

Guidance literature:: Multi-step reaction with 5 steps

1: p-TsOH / toluene / Heating

2: (S,S)-Mn(III)-salen complex; NaOCl; Na₂HPO₄ / CH₂Cl₂ / 0 - 20 °C

3: aq. NH₃ / ethanol / 50 °C

4: Et₃N / dimethylformamide; propan-2-ol / 20 °C

5: propan-2-ol

With ammonium hydroxide; sodium hypochlorite; disodium hydrogenphosphate; (S,S)-Mn(III)-salen; toluene-4-sulfonic acid; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1021/jm010183f