(trans)-9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecan-5-one

Base Information

Chemical Name:(trans)-9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecan-5-one
CAS No.:1392437-26-1
Molecular Formula:C₂₆H₂₄ClF₄N₅O₄
Molecular Weight:581.954
Hs Code.:

Synonyms:(trans)-9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecan-5-one

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Chemical Property of (trans)-9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecan-5-one

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Technology Process of (trans)-9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecan-5-one

There total 10 articles about (trans)-9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecan-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392437-25-0
(trans)-9-(4-chloro-7-methoxy-quinazolin-6-yloxy)-1-(2,2,2-trifluoroacetyl)-1,4-diaza-spiro[5.5]undecan-5-one

: 2106-04-9
3-chloro-2-fluoroaniline

: 1392437-26-1
(trans)-9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecan-5-one

Guidance literature:: In ethanol; at 80 ℃; for 2h;

Reference yield:

: 1263475-13-3
1,4-diaza-spiro[5.5]undecane-5,9-dione hydrochloride

: 1392437-26-1
(trans)-9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecan-5-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium methylate / methanol; acetonitrile / 3 h / 20 °C / Large scale

1.2: 16 h / Large scale

2.1: potassium carbonate; dmap / acetonitrile / 2.17 h / Large scale

3.1: sodium tetrahydroborate / water / 0.53 h / 3 °C / Large scale

4.1: triethylamine / 2-methyltetrahydrofuran / 0.75 h / 3 - 25 °C / Large scale

5.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.67 h / 50 - 55 °C / Large scale

6.1: palladium 10% on activated carbon; hydrogen / isopropyl alcohol; 1,4-dioxane / 4 h / 80 °C / Large scale

7.1: triphenylphosphine; N-chloro-succinimide / 1,4-dioxane; acetonitrile / 1.7 h / 60 - 90 °C

7.2: 3 h / 50 - 85 °C

8.1: ethanol / 2 h / 80 °C

With dmap; sodium tetrahydroborate; N-chloro-succinimide; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; sodium methylate; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 1392437-22-7
tert-butyl(trans)-9-(4-hydroxy-7-methoxy-quinazolin-6-yloxy)-5-oxo-1-(2,2,2-trifluoroacetyl)-1,4-diaza-spiro[5.5]undecane-4-carboxylate

: 1392437-26-1
(trans)-9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecan-5-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; N-chloro-succinimide / 1,4-dioxane; acetonitrile / 1.7 h / 60 - 90 °C

1.2: 3 h / 50 - 85 °C

2.1: ethanol / 2 h / 80 °C

With N-chloro-succinimide; triphenylphosphine; In 1,4-dioxane; ethanol; acetonitrile;