(E)-3-(2-Acetoxymethylphenyl)-2-propenyl acetate

Base Information

• Chemical Name: (E)-3-(2-Acetoxymethylphenyl)-2-propenyl acetate
• CAS No.: 126080-71-5
• Molecular Formula: C₁₄H₁₆O₄
• Molecular Weight: 248.279
• Mol file: 126080-71-5.mol

Synonyms:(E)-3-(2-Acetoxymethylphenyl)-2-propenyl acetate

Chemical Property of (E)-3-(2-Acetoxymethylphenyl)-2-propenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(2-Acetoxymethylphenyl)-2-propenyl acetate

There total 4 articles about (E)-3-(2-Acetoxymethylphenyl)-2-propenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(E)-3-(2-(hydroxymethyl)phenyl)prop-2-en-1-ol (126080-73-7) + acetic anhydride (108-24-7) → (E)-3-(2-Acetoxymethylphenyl)-2-propenyl acetate (126080-71-5)

Guidance literature:

With triethylamine; In toluene; at 50 ℃; for 18h;

DOI:10.1055/s-1989-27329

Reference yield:

(E)-o-carboxycinnamic acid (18454-53-0) → (E)-3-(2-Acetoxymethylphenyl)-2-propenyl acetate (126080-71-5)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂ / DMF / toluene / 2 h / 90 °C

2: toluene / 1 h / Heating

3: 88 percent / (i-Bu)2AlH / toluene / -30 °C

4: 98 percent / Et₃N / toluene / 18 h / 50 °C

With thionyl chloride; diisobutylaluminium hydride; triethylamine; N,N-dimethyl-formamide; In toluene;

DOI:10.1055/s-1989-27329

Reference yield:

2-(E)-[2-methoxycarbonylphenyl]acrylic acid methylester (34288-40-9,63600-27-1,18454-56-3) → (E)-3-(2-Acetoxymethylphenyl)-2-propenyl acetate (126080-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / (i-Bu)2AlH / toluene / -30 °C

2: 98 percent / Et₃N / toluene / 18 h / 50 °C

With diisobutylaluminium hydride; triethylamine; In toluene;

DOI:10.1055/s-1989-27329

upstream raw materials:

(E)-3-(2-(hydroxymethyl)phenyl)prop-2-en-1-ol

acetic anhydride

2-(E)-[2-methoxycarbonylphenyl]acrylic acid methylester

(E)-o-carboxycinnamic acid

Downstream raw materials:

6-(3-(2-hydroxymethylphenyl)-trans-prop-2-enyl)-5-hydroxy-2,3-dihydrobenzofuran