6-hydroxy-7-methoxy-2-(4-methoxybenzyl)-3,4-dihydroisoquinolin-1(2H)-one

Base Information

Chemical Name:6-hydroxy-7-methoxy-2-(4-methoxybenzyl)-3,4-dihydroisoquinolin-1(2H)-one
CAS No.:1064200-95-8
Molecular Formula:C₁₈H₁₉NO₄
Molecular Weight:313.353
Hs Code.:

Synonyms:6-hydroxy-7-methoxy-2-(4-methoxybenzyl)-3,4-dihydroisoquinolin-1(2H)-one

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Chemical Property of 6-hydroxy-7-methoxy-2-(4-methoxybenzyl)-3,4-dihydroisoquinolin-1(2H)-one

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Technology Process of 6-hydroxy-7-methoxy-2-(4-methoxybenzyl)-3,4-dihydroisoquinolin-1(2H)-one

There total 7 articles about 6-hydroxy-7-methoxy-2-(4-methoxybenzyl)-3,4-dihydroisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1064207-17-5
6-(benzyloxy)-7-methoxy-2-(4-methoxybenzyl)-3,4-dihydro-2H-isoquinolin-1-one

: 1064200-95-8
6-hydroxy-7-methoxy-2-(4-methoxybenzyl)-3,4-dihydroisoquinolin-1(2H)-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 69.0%

: 1064200-86-7
7-methoxy-6-(triisopropylsilyloxy)-2-(4-methoxybenzyl)-3,4-dihydroisoquinolin-1(2H)-one

: 1064200-95-8
6-hydroxy-7-methoxy-2-(4-methoxybenzyl)-3,4-dihydroisoquinolin-1(2H)-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1002/cmdc.201400017

Reference yield:

: 2107-69-9
5,6-dimethoxy-1-indanone

: 1064200-95-8
6-hydroxy-7-methoxy-2-(4-methoxybenzyl)-3,4-dihydroisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: piperidine / water / 192 h / 140 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

3.1: methanesulfonic acid; sodium azide / dichloromethane / 16 h / 0 - 20 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol; tetrahydrofuran / 20 °C

5.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

6.2: 6 h / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

With piperidine; 1H-imidazole; sodium azide; methanesulfonic acid; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201400017