cis-5'-O-[4-(S)-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl]-2'-C-methyladenosine

Base Information

Chemical Name:cis-5'-O-[4-(S)-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl]-2'-C-methyladenosine
CAS No.:862189-29-5
Molecular Formula:C₂₀H₂₃ClN₅O₇P
Molecular Weight:511.859
Hs Code.:

Synonyms:cis-5'-O-[4-(S)-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl]-2'-C-methyladenosine

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Chemical Property of cis-5'-O-[4-(S)-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl]-2'-C-methyladenosine

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Technology Process of cis-5'-O-[4-(S)-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl]-2'-C-methyladenosine

There total 4 articles about cis-5'-O-[4-(S)-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl]-2'-C-methyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 951663-21-1
C₂₃H₂₇ClN₅O₇P

: 862189-29-5
cis-5'-O-[4-(S)-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl]-2'-C-methyladenosine

Guidance literature:: With trifluoroacetic acid; at 0 - 20 ℃;
DOI:10.1021/jm0701021

Reference yield:

: 16434-54-1
2′,3′-O-isoproylidene-β-2′-methyladenosine

: 862189-29-5
cis-5'-O-[4-(S)-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl]-2'-C-methyladenosine

Guidance literature:: Multi-step reaction with 2 steps

1.1: t-butylmagnesium chloride / tetrahydrofuran; dimethylformamide / 0.33 h / 0 °C

1.2: 56 percent / tetrahydrofuran; dimethylformamide / 3 h / 20 °C

2.1: 62 percent / aq. CF₃CO₂H / 0 - 20 °C

With tert-butylmagnesium chloride; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm0701021

Reference yield:

: 15397-12-3
2'-C-methyladenosine

: 862189-29-5
cis-5'-O-[4-(S)-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl]-2'-C-methyladenosine

Guidance literature:: Multi-step reaction with 3 steps

1.1: HC(OMe)3; p-TsOH*H₂O / dimethylformamide

2.1: t-butylmagnesium chloride / tetrahydrofuran; dimethylformamide / 0.33 h / 0 °C

2.2: 56 percent / tetrahydrofuran; dimethylformamide / 3 h / 20 °C

3.1: 62 percent / aq. CF₃CO₂H / 0 - 20 °C

With tert-butylmagnesium chloride; toluene-4-sulfonic acid; trifluoroacetic acid; trimethyl orthoformate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm0701021