N2-ACETYL-9-[(2'-HYDROXYETHOXY)METHYL]GUANINE

Base Information

• Chemical Name: N2-ACETYL-9-[(2'-HYDROXYETHOXY)METHYL]GUANINE
• CAS No.: 110104-37-5
• Molecular Formula: C10H13N5O4
• Molecular Weight: 267.244
• Hs Code.: 2933599550
• Mol file: 110104-37-5.mol

Synonyms:9-[(2-Hydroxyethoxy)methyl]-N2-acetylguanine;N2-Acetylaciclovir;

Chemical Property of N2-ACETYL-9-[(2'-HYDROXYETHOXY)METHYL]GUANINE

Chemical Property:

• Melting Point: 217℃
• PKA: pKa 8.54±0.03(H2O t=RT I=0.25 ) (Uncertain)
• PSA: 122.13000
• Density: 1.63 g/cm³
• LogP: -0.88260
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly. Heated), Methanol (Slightly, Heated, Sonicated), Water (Very Sli

Purity/Quality:

98%min ^*data from raw suppliers

N2-Acetyl Acyclovir ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N2-ACETYL-9-[(2'-HYDROXYETHOXY)METHYL]GUANINE

There total 8 articles about N2-ACETYL-9-[(2'-HYDROXYETHOXY)METHYL]GUANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acycloguanosine (59277-89-3) + acetic anhydride (108-24-7) → 2-acetylamino-9-<(2-hydroxyethoxy)methyl>-1,9-dihydro-6H-purin-6-one (110104-37-5)

Guidance literature:

With dmap; for 120h; Ambient temperature;

DOI:10.1021/jm00158a011

Reference yield: 78.0%

→ 2-acetylamino-9-<(2-hydroxyethoxy)methyl>-1,9-dihydro-6H-purin-6-one (110104-37-5)

Guidance literature:

Reference yield: 67.0%

2-acetylamino-9-(2-acetoxyethoxymethyl)purine-6-one (75128-73-3) → 2-acetylamino-9-<(2-hydroxyethoxy)methyl>-1,9-dihydro-6H-purin-6-one (110104-37-5)

Guidance literature:

With sodium methylate; In methanol; at 23 ℃; for 0.266667h;

DOI:10.1081/SCC-100104050

upstream raw materials:

2-acetylamino-9-(2-acetoxyethoxymethyl)purine-6-one

acycloguanosine

acetic anhydride

9-<(2-acetoxyethoxy)methyl>-2-acetylamino-6-(p-fluorobenzenesulfonyloxy)-9H-purine

Downstream raw materials:

Acetic acid 2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-ethyl ester

9-<<2-<<(Carboxymethyl)hydroxyphosphinyl>oxy>ethoxy>methyl>guanine Disodium Salt

N²-(p-anisyldiphenylmethyl)-9-<(2-hydroxyethoxy)methyl>guanine

(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-acetaldehyde