2-chloro-4-{[2-methyl-1-(1-methylethyl)-1H-benzimidazol-7-yl]ethynyl}-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Name:2-chloro-4-{[2-methyl-1-(1-methylethyl)-1H-benzimidazol-7-yl]ethynyl}-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine
CAS No.:1147015-19-7
Molecular Formula:C₂₆H₂₂ClN₅O₂S
Molecular Weight:504.012
Hs Code.:

Synonyms:2-chloro-4-{[2-methyl-1-(1-methylethyl)-1H-benzimidazol-7-yl]ethynyl}-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Property of 2-chloro-4-{[2-methyl-1-(1-methylethyl)-1H-benzimidazol-7-yl]ethynyl}-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

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Technology Process of 2-chloro-4-{[2-methyl-1-(1-methylethyl)-1H-benzimidazol-7-yl]ethynyl}-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

There total 8 articles about 2-chloro-4-{[2-methyl-1-(1-methylethyl)-1H-benzimidazol-7-yl]ethynyl}-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1147015-18-6
2-chloro-4-{[2-methyl-1-(1-methylethyl)-1H-benzimidazol-7-yl]ethynyl}-7H-pyrrolo[2,3-d]pyrimidine

: 98-59-9
p-toluenesulfonyl chloride

: 1147015-19-7
2-chloro-4-{[2-methyl-1-(1-methylethyl)-1H-benzimidazol-7-yl]ethynyl}-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: 2-chloro-4-{[2-methyl-1-(1-methylethyl)-1H-benzimidazol-7-yl]ethynyl}-7H-pyrrolo[2,3-d]pyrimidine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

p-toluenesulfonyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1147015-12-0
7-bromo-1-isopropyl-2-methyl-1H-benzoimidazole

: 1147015-19-7
2-chloro-4-{[2-methyl-1-(1-methylethyl)-1H-benzimidazol-7-yl]ethynyl}-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.08 h

1.2: 1 h / 130 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 1 h / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1147015-08-4
N-(2-bromo-6-nitro-phenyl)-N-isopropyl-acetamide

: 1147015-19-7
2-chloro-4-{[2-methyl-1-(1-methylethyl)-1H-benzimidazol-7-yl]ethynyl}-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; water; tin(ll) chloride / 1.17 h / 20 °C / Heating / reflux

1.2: pH 14 / Cooling with acetone-ice

2.1: toluene-4-sulfonic acid / ethyl acetate / 20 °C

3.1: tetrabutyl ammonium fluoride / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.08 h

3.2: 1 h / 130 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 1 h / 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; water; sodium hydride; toluene-4-sulfonic acid; tin(ll) chloride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;