(S)-2-(1-(4-(o-tolylthio)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Base Information

Chemical Name:(S)-2-(1-(4-(o-tolylthio)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt
CAS No.:1283142-65-3
Molecular Formula:C₂HF₃O₂*C₁₉H₂₁NO₂S
Molecular Weight:441.471
Hs Code.:

Synonyms:(S)-2-(1-(4-(o-tolylthio)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

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Chemical Property of (S)-2-(1-(4-(o-tolylthio)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

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Technology Process of (S)-2-(1-(4-(o-tolylthio)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

There total 7 articles about (S)-2-(1-(4-(o-tolylthio)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1283146-21-3
(S)-2-(1-(4-(o-tolylthio)phenyl)pyrrolidin-2-yl)acetonitrile

: 76-05-1
trifluoroacetic acid

: 1283142-65-3
(S)-2-(1-(4-(o-tolylthio)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: (S)-2-(1-(4-(o-tolylthio)phenyl)pyrrolidin-2-yl)acetonitrile; With hydrogenchloride; acetic acid; In water; at 100 ℃; for 0.333333h; Sealed tube; Microwave irradiation;

trifluoroacetic acid; In water; acetonitrile;
DOI:10.1021/acs.jmedchem.6b01559

Reference yield:

: 1-(4-fluorophenylsulfonyl)-2-methylbenzene

: 1283142-65-3
(S)-2-(1-(4-(o-tolylthio)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1: dimethyl sulfoxide / 6 h / 130 °C

2: diisobutylaluminium hydride / toluene / 16 h / Reflux

3: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

4: dimethyl sulfoxide / 50 °C / Inert atmosphere

5: hydrogenchloride; acetic acid / water / 0.33 h / 100 °C / Sealed tube; Microwave irradiation

With hydrogenchloride; diisobutylaluminium hydride; acetic acid; triethylamine; In dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1021/acs.jmedchem.6b01559

Reference yield:

: 133-59-5
Toluene-2-sulfonyl chloride

: 1283142-65-3
(S)-2-(1-(4-(o-tolylthio)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 6 steps

1: iron(III) chloride / 60 °C

2: dimethyl sulfoxide / 6 h / 130 °C

3: diisobutylaluminium hydride / toluene / 16 h / Reflux

4: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

5: dimethyl sulfoxide / 50 °C / Inert atmosphere

6: hydrogenchloride; acetic acid / water / 0.33 h / 100 °C / Sealed tube; Microwave irradiation

With hydrogenchloride; iron(III) chloride; diisobutylaluminium hydride; acetic acid; triethylamine; In dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1021/acs.jmedchem.6b01559