(S)-6-Benzenesulfonyl-2-tert-butoxycarbonylamino-6-cyano-hexanoic acid tert-butyl ester

Base Information

Chemical Name:(S)-6-Benzenesulfonyl-2-tert-butoxycarbonylamino-6-cyano-hexanoic acid tert-butyl ester
CAS No.:173690-60-3
Molecular Formula:C₂₂H₃₂N₂O₆S
Molecular Weight:452.572
Hs Code.:

Synonyms:(S)-6-Benzenesulfonyl-2-tert-butoxycarbonylamino-6-cyano-hexanoic acid tert-butyl ester

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Chemical Property of (S)-6-Benzenesulfonyl-2-tert-butoxycarbonylamino-6-cyano-hexanoic acid tert-butyl ester

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Technology Process of (S)-6-Benzenesulfonyl-2-tert-butoxycarbonylamino-6-cyano-hexanoic acid tert-butyl ester

There total 1 articles about (S)-6-Benzenesulfonyl-2-tert-butoxycarbonylamino-6-cyano-hexanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: C₈H₆NO₂S^(1-)

: 173690-59-0
(tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-5-iodopentanoate)

: 173690-60-3
(S)-6-Benzenesulfonyl-2-tert-butoxycarbonylamino-6-cyano-hexanoic acid tert-butyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 23 ℃;
DOI:10.1016/0960-894X(95)00569-F

Reference yield:

: 173690-60-3
(S)-6-Benzenesulfonyl-2-tert-butoxycarbonylamino-6-cyano-hexanoic acid tert-butyl ester

: (S)-7-Amino-6-benzenesulfonyl-2-tert-butoxycarbonylamino-7-[(Z)-tert-butoxycarbonylimino]-heptanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) hydroxylamine hydrochloride, sodium bicarbonate / 1) ethanol, water, 1 h, reflux; 2) ethyl acetate, 23 deg C, 45 min

2: 80 percent / H₂, di-t-butyl dicarbonate / Pd-C / ethyl acetate

With di-tert-butyl dicarbonate; hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In ethyl acetate;
DOI:10.1016/0960-894X(95)00569-F

Reference yield:

: 173690-60-3
(S)-6-Benzenesulfonyl-2-tert-butoxycarbonylamino-6-cyano-hexanoic acid tert-butyl ester

: (S)-2-Amino-6-carbamimidoyl-hexanoic acid; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) hydroxylamine hydrochloride, sodium bicarbonate / 1) ethanol, water, 1 h, reflux; 2) ethyl acetate, 23 deg C, 45 min

2: 80 percent / H₂, di-t-butyl dicarbonate / Pd-C / ethyl acetate

3: 94 percent / Na/Hg, disodium hydrogen phosphate / methanol / 0 °C / 760 Torr

4: 82 percent / aq. HCl / dioxane / 18 h / 23 °C

With hydrogenchloride; disodium hydrogenphosphate; sodium amalgam; di-tert-butyl dicarbonate; hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; ethyl acetate;
DOI:10.1016/0960-894X(95)00569-F