2-{[1-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]thio}-5-[(1-methyl-1H-pyrazol-4-yl)methyl]-4(1H)-pyrimidinone

Base Information

Chemical Name:2-{[1-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]thio}-5-[(1-methyl-1H-pyrazol-4-yl)methyl]-4(1H)-pyrimidinone
CAS No.:1380427-65-5
Molecular Formula:C₂₄H₂₀ClF₃N₄O₂S
Molecular Weight:520.963
Hs Code.:

Synonyms:2-{[1-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]thio}-5-[(1-methyl-1H-pyrazol-4-yl)methyl]-4(1H)-pyrimidinone

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Chemical Property of 2-{[1-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]thio}-5-[(1-methyl-1H-pyrazol-4-yl)methyl]-4(1H)-pyrimidinone

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Technology Process of 2-{[1-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]thio}-5-[(1-methyl-1H-pyrazol-4-yl)methyl]-4(1H)-pyrimidinone

There total 9 articles about 2-{[1-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]thio}-5-[(1-methyl-1H-pyrazol-4-yl)methyl]-4(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.58%

: 224776-34-5
5-[(1-methyl-1H-pyrazol-4-yl)methyl]-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone

: 1380429-76-4
1-chloro-4-{[4-(1-chloroethyl)phenyl]oxy}-2-(trifluoromethyl)benzene

: 1380427-65-5
2-{[1-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]thio}-5-[(1-methyl-1H-pyrazol-4-yl)methyl]-4(1H)-pyrimidinone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 25016-11-9
1-methylpyrazole-4-carbaldehyde

: 1380427-65-5
2-{[1-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]thio}-5-[(1-methyl-1H-pyrazol-4-yl)methyl]-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 5 steps

1.1: piperidine; pyridine / 4 h / 110 °C / Inert atmosphere

1.2: pH 1

2.1: methanol; sulfuric acid / 4 h / Reflux

3.1: hydrogen / palladium on activated charcoal / ethanol / 12 h / 20 - 40 °C

4.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

4.2: 50 °C

4.3: 1 h / pH 3 / Cooling with ice

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 130 °C / Microwave irradiation

With piperidine; pyridine; methanol; sulfuric acid; potassium tert-butylate; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 689251-97-6
(E)-3-(1-methyl-1H-pyrazol-4-yl)acrylic acid

: 1380427-65-5
2-{[1-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]thio}-5-[(1-methyl-1H-pyrazol-4-yl)methyl]-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; sulfuric acid / 4 h / Reflux

2.1: hydrogen / palladium on activated charcoal / ethanol / 12 h / 20 - 40 °C

3.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

3.2: 50 °C

3.3: 1 h / pH 3 / Cooling with ice

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 130 °C / Microwave irradiation

With methanol; sulfuric acid; potassium tert-butylate; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;