4,5,6,7-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridine

Base Information

• Chemical Name: 4,5,6,7-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridine
• CAS No.: 109904-25-8
• Molecular Formula: C26H23 N S
• Molecular Weight: 381.541
• Hs Code.: 2934999090
• Mol file: 109904-25-8.mol

Synonyms:5-Trityl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Chemical Property of 4,5,6,7-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridine

Chemical Property:

• Melting Point: 950C
• Refractive Index: 1.652
• PSA: 31.48000
• LogP: 6.03620
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

4,5,6,7-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,5,6,7-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridine (cas# 109904-25-8) is a compound useful in organic synthesis.

Technology Process of 4,5,6,7-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridine

There total 11 articles about 4,5,6,7-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trityl chloride (76-83-5) + 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride (28783-41-7) → N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (109904-25-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.joc.5b00632

Reference yield: 96.0%

4,5,6,7-tetrahydrothieno[3,2-c]pyridine (54903-50-3) + trityl chloride (76-83-5) → N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (109904-25-8)

Guidance literature:

With triethylamine; In dichloromethane; water;

Reference yield: 66.0%

N-trityl-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine (934351-23-2) → N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (109904-25-8)

Guidance literature:

With sulfuryl dichloride; triethylamine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/ja069059h

upstream raw materials:

N-trityl-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine

N-(tert-butoxycarbonyl)-1,2,5,6-tetrahydropyridine-3-carbaldehyde

N-trityl-1,2,5,6-tetrahydropyridine-3-carbaldehyde

5-oxiranyl-N-trityl-1,2,3,6-tetrahydropyridine

Downstream raw materials:

4,5,6,7-tetrahydrothieno[3,2-c]pyridine

5-triphenylmethyl-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine

2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

C₇H₁₀BNO₂S*C₇H₈O₃S

Refernces

• 1、 -. "PROCESS FOR PREPARING A PHARMACEUTICAL COMPOUND". Paragraph 0040-0046. . Retrieved 2013/03/26.
• 2、 -. "AN IMPROVED PROCESS FOR THE PREPARATION OF PRASUGREL HYDROCHLORIDE AND ITS INTERMEDIATES". Page/Page column 18. . Retrieved 2012/01/14.