4-(4-hydroxyphenyl)-3-thiosemicarbazide

Base Information

• Chemical Name: 4-(4-hydroxyphenyl)-3-thiosemicarbazide
• CAS No.: 68372-10-1
• Molecular Formula: C₇H₉N₃OS
• Molecular Weight: 183.234
• Mol file: 68372-10-1.mol

Synonyms:4-(4-hydroxyphenyl)-3-thiosemicarbazide

Chemical Property of 4-(4-hydroxyphenyl)-3-thiosemicarbazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-hydroxyphenyl)-3-thiosemicarbazide

There total 5 articles about 4-(4-hydroxyphenyl)-3-thiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + 4-amino-phenol (123-30-8) → 4-(4-hydroxyphenyl)-3-thiosemicarbazide (68372-10-1)

Guidance literature:

carbon disulfide; 4-amino-phenol; With potassium hydroxide; In tetrahydrofuran;

With hydrazine hydrate;

DOI:10.1016/j.ejps.2003.08.002

Reference yield:

ammonium p-hydroxydithiocarbanilate (30714-45-5) → 4-(4-hydroxyphenyl)-3-thiosemicarbazide (68372-10-1)

Guidance literature:

With sodium monochloroacetic acid; hydrazine hydrate; In ethanol;

Reference yield:

4-amino-phenol (123-30-8) → 4-(4-hydroxyphenyl)-3-thiosemicarbazide (68372-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1: liq. NH₃ / -30 °C

2: hydrazine hydrate, sodium chloroacetate / aq. ethanol

With ammonia; sodium monochloroacetic acid; hydrazine hydrate; In ethanol;

upstream raw materials:

ammonium p-hydroxydithiocarbanilate

carbon disulfide

4-amino-phenol

C₁₂H₁₇N₃O₃S

Downstream raw materials:

benzaldehyde 4-(4-hydroxy-phenyl)-thiosemicarbazone

5-(4-hydroxy-anilino)-3H-[1,3,4]thiadiazole-2-thione

(Z)-N-(4-hydroxyphenyl)-2-(2-oxoindolin-3-ylidene)hydrazinecarbothioamide

Refernces

• 1、 Yogeeswari,Sriram,Saraswat,Ragavendran, J. Vaigunda,Kumar, M. Mohan,Murugesan,Thirumurugan,Stables. "Synthesis and anticonvulsant and neurotoxicity evaluation of N 4-phthalimido phenyl (thio) semicarbazides". . p. 341 - 346. Retrieved 2007/10/03.