2-(3-(1-benzyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-4-methoxyphenyl)acetic acid

Base Information

Chemical Name:2-(3-(1-benzyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-4-methoxyphenyl)acetic acid
CAS No.:721947-91-7
Molecular Formula:C₂₅H₂₂N₂O₄
Molecular Weight:414.461
Hs Code.:

Synonyms:2-(3-(1-benzyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-4-methoxyphenyl)acetic acid

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Chemical Property of 2-(3-(1-benzyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-4-methoxyphenyl)acetic acid

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Technology Process of 2-(3-(1-benzyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-4-methoxyphenyl)acetic acid

There total 6 articles about 2-(3-(1-benzyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-4-methoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 721948-31-8
C₂₆H₂₄N₂O₄

: 721947-91-7
2-(3-(1-benzyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-4-methoxyphenyl)acetic acid

Guidance literature:: C₂₆H₂₄N₂O₄; With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃;

In tetrahydrofuran; methanol; water; pH=3; Acidic conditions;
DOI:10.1021/ml200019y

Reference yield:

: 721948-26-1
methyl 2-(4-methoxy-3-(2-nitrobenzoyl)phenyl)acetate

: 721947-91-7
2-(3-(1-benzyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-4-methoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: iron; acetic acid / water / 65 °C

2.1: pyridine / 36 h / 130 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

4.2: pH 3 / Acidic conditions

With pyridine; potassium tert-butylate; iron; acetic acid; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ml200019y

Reference yield:

: 721948-27-2
methyl 2-(3-(2-aminobenzoyl)-4-methoxyphenyl)acetate

: 721947-91-7
2-(3-(1-benzyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-4-methoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 36 h / 130 °C

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

3.2: pH 3 / Acidic conditions

With pyridine; potassium tert-butylate; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ml200019y