[4-(5-O-4,4'-dimethoxytrityl-β-D-ribofuranosyl)imidazol-1-yl]methyl 2,2-dimethylpropiolate

Base Information

Chemical Name:[4-(5-O-4,4'-dimethoxytrityl-β-D-ribofuranosyl)imidazol-1-yl]methyl 2,2-dimethylpropiolate
CAS No.:689260-64-8
Molecular Formula:C₃₅H₄₀N₂O₈
Molecular Weight:616.711
Hs Code.:

Synonyms:[4-(5-O-4,4'-dimethoxytrityl-β-D-ribofuranosyl)imidazol-1-yl]methyl 2,2-dimethylpropiolate

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Chemical Property of [4-(5-O-4,4'-dimethoxytrityl-β-D-ribofuranosyl)imidazol-1-yl]methyl 2,2-dimethylpropiolate

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Technology Process of [4-(5-O-4,4'-dimethoxytrityl-β-D-ribofuranosyl)imidazol-1-yl]methyl 2,2-dimethylpropiolate

There total 7 articles about [4-(5-O-4,4'-dimethoxytrityl-β-D-ribofuranosyl)imidazol-1-yl]methyl 2,2-dimethylpropiolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 689260-62-6
[4-(β-D-ribofuranosyl)imidazol-1-yl]methyl 2,2-dimethylpropiolate

: 689260-64-8
[4-(5-O-4,4'-dimethoxytrityl-β-D-ribofuranosyl)imidazol-1-yl]methyl 2,2-dimethylpropiolate

Guidance literature:: With pyridine; dmap; triethylamine;
DOI:10.1016/j.tet.2005.09.063

Reference yield:

: 18997-19-8
Chloromethyl pivalate

: 689260-64-8
[4-(5-O-4,4'-dimethoxytrityl-β-D-ribofuranosyl)imidazol-1-yl]methyl 2,2-dimethylpropiolate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 3 h / 20 °C

1.2: 94 percent / tetrahydrofuran / 1 h / 20 °C

2.1: 100 percent / cyclohexene / Pd(OH)2/C / ethanol / 3 h / Heating

3.1: 80 percent / pyridine; Et₃N; DMAP

With pyridine; dmap; sodium hydride; triethylamine; cyclohexene; palladium dihydroxide; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tet.2005.09.063

Reference yield:

: 169139-31-5
4(5)-2,3,5-tri-O-benzyl-β-D-ribofuranosylimidazole

: 689260-64-8
[4-(5-O-4,4'-dimethoxytrityl-β-D-ribofuranosyl)imidazol-1-yl]methyl 2,2-dimethylpropiolate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 3 h / 20 °C

1.2: 94 percent / tetrahydrofuran / 1 h / 20 °C

2.1: 100 percent / cyclohexene / Pd(OH)2/C / ethanol / 3 h / Heating

3.1: 80 percent / pyridine; Et₃N; DMAP

With pyridine; dmap; sodium hydride; triethylamine; cyclohexene; palladium dihydroxide; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tet.2005.09.063