1-{5-[(S)-1-(4-Methoxy-benzyl)-4,5-diphenyl-1H-imidazole-2-sulfinyl]-pentyl}-3,5-dimethyl-1H-pyrazole

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Chemical Name:1-{5-[(S)-1-(4-Methoxy-benzyl)-4,5-diphenyl-1H-imidazole-2-sulfinyl]-pentyl}-3,5-dimethyl-1H-pyrazole
CAS No.:154416-28-1
Molecular Formula:C₃₃H₃₆N₄O₂S
Molecular Weight:552.74
Hs Code.:

Synonyms:1-{5-[(S)-1-(4-Methoxy-benzyl)-4,5-diphenyl-1H-imidazole-2-sulfinyl]-pentyl}-3,5-dimethyl-1H-pyrazole

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Chemical Property of 1-{5-[(S)-1-(4-Methoxy-benzyl)-4,5-diphenyl-1H-imidazole-2-sulfinyl]-pentyl}-3,5-dimethyl-1H-pyrazole

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Technology Process of 1-{5-[(S)-1-(4-Methoxy-benzyl)-4,5-diphenyl-1H-imidazole-2-sulfinyl]-pentyl}-3,5-dimethyl-1H-pyrazole

There total 5 articles about 1-{5-[(S)-1-(4-Methoxy-benzyl)-4,5-diphenyl-1H-imidazole-2-sulfinyl]-pentyl}-3,5-dimethyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 67-51-6
3,5-dimethyl-1H-pyrazole

: 154416-27-0
2-((S)-5-Chloro-pentane-1-sulfinyl)-1-(4-methoxy-benzyl)-4,5-diphenyl-1H-imidazole

: 154416-28-1
1-{5-[(S)-1-(4-Methoxy-benzyl)-4,5-diphenyl-1H-imidazole-2-sulfinyl]-pentyl}-3,5-dimethyl-1H-pyrazole

Guidance literature:: With 1-methyl-pyrrolidin-2-one; sodium hydride; sodium iodide; at 80 ℃; for 4h;
DOI:10.1016/0040-4039(94)85087-9

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 154416-28-1
1-{5-[(S)-1-(4-Methoxy-benzyl)-4,5-diphenyl-1H-imidazole-2-sulfinyl]-pentyl}-3,5-dimethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) DMI; 2.) t-BuOK / 1.) THF, r.t., 30 min.; 2.) THF, ref., 1 h

2: 71 percent / cumene hydroperoxide, Ti(OiPr)4, L-diethyltartarate / H₂O; CH₂Cl₂ / -20 °C

3: DMI, LDA / tetrahydrofuran / from -20 deg C to r.t.

4: 50 percent / NaI, NaH, NMP / 4 h / 80 °C

With 1-methyl-pyrrolidin-2-one; titanium(IV) isopropylate; desipramine; diethyl (2R,3R)-tartrate; Cumene hydroperoxide; potassium tert-butylate; sodium hydride; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/0040-4039(94)85087-9

Reference yield:

: 146982-51-6
2-methylthio-4,5-diphenyl-1-(4-methoxybenzyl)imidazole

: 154416-28-1
1-{5-[(S)-1-(4-Methoxy-benzyl)-4,5-diphenyl-1H-imidazole-2-sulfinyl]-pentyl}-3,5-dimethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / cumene hydroperoxide, Ti(OiPr)4, L-diethyltartarate / H₂O; CH₂Cl₂ / -20 °C

2: DMI, LDA / tetrahydrofuran / from -20 deg C to r.t.

3: 50 percent / NaI, NaH, NMP / 4 h / 80 °C

With 1-methyl-pyrrolidin-2-one; titanium(IV) isopropylate; desipramine; diethyl (2R,3R)-tartrate; Cumene hydroperoxide; sodium hydride; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/0040-4039(94)85087-9