2-acetylamino-7-hydroxy-6-phenylthio-3-carbethoxybenzothiophene

Base Information

• Chemical Name: 2-acetylamino-7-hydroxy-6-phenylthio-3-carbethoxybenzothiophene
• CAS No.: 136918-55-3
• Molecular Formula: C₁₉H₁₇NO₄S₂
• Molecular Weight: 387.48
• Mol file: 136918-55-3.mol

Synonyms:2-acetylamino-7-hydroxy-6-phenylthio-3-carbethoxybenzothiophene

Chemical Property of 2-acetylamino-7-hydroxy-6-phenylthio-3-carbethoxybenzothiophene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-acetylamino-7-hydroxy-6-phenylthio-3-carbethoxybenzothiophene

There total 1 articles about 2-acetylamino-7-hydroxy-6-phenylthio-3-carbethoxybenzothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.4%

2-Acetylamino-7-oxo-6-phenylsulfanyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester (128811-97-2) → 2-acetylamino-7-hydroxy-6-phenylthio-3-carbethoxybenzothiophene (136918-55-3)

Guidance literature:

With bromine; In chloroform; for 1h; Heating;

DOI:10.1007/BF00480844

Reference yield: 53.9%

2-acetylamino-7-hydroxy-6-phenylthio-3-carbethoxybenzothiophene (136918-55-3) → 2-amino-7-hydroxy-6-phenylthio-3-carbethoxybenzothiophene (136918-52-0)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃; for 1.5h;

DOI:10.1007/BF00480844

Reference yield:

2-acetylamino-7-hydroxy-6-phenylthio-3-carbethoxybenzothiophene (136918-55-3) → 8-hydroxy-7-phenylthio-2,3-trimethylene-4-oxo-3,4-dihydrobenzothieno<2,3-d>pyrimidine (136918-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 53.9 percent / NaOH / H₂O; ethanol / 1.5 h / 20 °C

2: 54.7 percent / POCl₃ / CH₂Cl₂ / 1.5 h / Heating

With sodium hydroxide; trichlorophosphate; In ethanol; dichloromethane; water;

DOI:10.1007/BF00480844

upstream raw materials:

2-Acetylamino-7-oxo-6-phenylsulfanyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester

Downstream raw materials:

2-amino-7-hydroxy-6-phenylthio-3-carbethoxybenzothiophene

8-hydroxy-7-phenylthio-2,3-trimethylene-4-oxo-3,4-dihydrobenzothieno<2,3-d>pyrimidine

8-hydroxy-7-phenylthio-2,3-pentamethylene-4-oxo-3,4-dihydrobenzothieno<2,3-d>pyrimidine