(2E,4E)-5-((3R,5S)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3-methylpenta-2,4-dienal

Base Information

Chemical Name:(2E,4E)-5-((3R,5S)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3-methylpenta-2,4-dienal
CAS No.:1449674-40-1
Molecular Formula:C₂₁H₃₆O₃Si
Molecular Weight:364.601
Hs Code.:

Synonyms:(2E,4E)-5-((3R,5S)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3-methylpenta-2,4-dienal

Suppliers and Price of (2E,4E)-5-((3R,5S)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3-methylpenta-2,4-dienal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2E,4E)-5-((3R,5S)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3-methylpenta-2,4-dienal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2E,4E)-5-((3R,5S)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3-methylpenta-2,4-dienal

There total 13 articles about (2E,4E)-5-((3R,5S)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3-methylpenta-2,4-dienal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1449674-32-1
(2E,4E)-5-((3R,5S)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3-methylpenta-2,4-dienenitrile

: 1449674-40-1
(2E,4E)-5-((3R,5S)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3-methylpenta-2,4-dienal

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -20 - 20 ℃; for 6h;
DOI:10.1039/c3ob41226a

Reference yield:

: 1449674-39-8
(3R,5S)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-2,6,6-trimethylcyclohex-1-enecarbaldehyde

: 1449674-40-1
(2E,4E)-5-((3R,5S)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3-methylpenta-2,4-dienal

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 20 °C

1.2: 2 h / 0 - 20 °C

2.1: diisobutylaluminium hydride / toluene / 6 h / -20 - 20 °C

With n-butyllithium; diisobutylaluminium hydride; In tetrahydrofuran; hexane; toluene; 1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1039/c3ob41226a

Reference yield:

: 1449674-47-8
C₁₇H₂₈O₄

: 1449674-40-1
(2E,4E)-5-((3R,5S)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3-methylpenta-2,4-dienal

Guidance literature:: Multi-step reaction with 11 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 °C / Inert atmosphere

2.1: bis(cyclopentadienyl)titanium dichloride; manganese / tetrahydrofuran / 6 h / 40 °C / Inert atmosphere

3.1: sodium hydroxide / water; methanol / 20 °C

4.1: triethylamine / dichloromethane / -40 °C

5.1: 2,6-dimethylpyridine / dichloromethane / 20 °C

6.1: sodium hydroxide / water; methanol / 20 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

8.1: Dess-Martin periodane / dichloromethane / 0.25 h / 20 °C

9.1: pyrrolidine / diethyl ether / 20 °C

10.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 20 °C

10.2: 2 h / 0 - 20 °C

11.1: diisobutylaluminium hydride / toluene / 6 h / -20 - 20 °C

With pyrrolidine; 2,6-dimethylpyridine; bis(cyclopentadienyl)titanium dichloride; manganese; n-butyllithium; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; toluene; 10.1: |Horner-Wadsworth-Emmons Olefination / 10.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1039/c3ob41226a