2',6'-dimethyl-4'-methoxycarbonylphenyl 2-isopropyloxyacridine-9-carboxylate

Base Information

• Chemical Name: 2',6'-dimethyl-4'-methoxycarbonylphenyl 2-isopropyloxyacridine-9-carboxylate
• CAS No.: 1286282-27-6
• Molecular Formula: C₂₇H₂₅NO₅
• Molecular Weight: 443.499
• Mol file: 1286282-27-6.mol

Synonyms:2',6'-dimethyl-4'-methoxycarbonylphenyl 2-isopropyloxyacridine-9-carboxylate

Chemical Property of 2',6'-dimethyl-4'-methoxycarbonylphenyl 2-isopropyloxyacridine-9-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',6'-dimethyl-4'-methoxycarbonylphenyl 2-isopropyloxyacridine-9-carboxylate

There total 9 articles about 2',6'-dimethyl-4'-methoxycarbonylphenyl 2-isopropyloxyacridine-9-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C24H19NO5 (1307863-96-2) + isopropyl alcohol (67-63-0,8013-70-5) → 2',6'-dimethyl-4'-methoxycarbonylphenyl 2-isopropyloxyacridine-9-carboxylate (1286282-27-6)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c2ob00022a

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) → 2',6'-dimethyl-4'-methoxycarbonylphenyl 2-isopropyloxyacridine-9-carboxylate (1286282-27-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 145 °C / Inert atmosphere

2.1: potassium hydroxide / water / 4 h / Inert atmosphere; Reflux

3.1: pyridine; p-toluenesulfonyl chloride / 4 h / 20 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / 4 h / 20 °C

4.2: 16 h / 0 - 20 °C

5.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With pyridine; di-isopropyl azodicarboxylate; boron tribromide; sodium hydride; p-toluenesulfonyl chloride; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 5.1: Mitsunobu reaction;

DOI:10.1039/c2ob00022a

Reference yield:

C9H9ClO2 (42293-38-9) → 2',6'-dimethyl-4'-methoxycarbonylphenyl 2-isopropyloxyacridine-9-carboxylate (1286282-27-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 48 h / 20 °C / Inert atmosphere

2.1: pyridine; p-toluenesulfonyl chloride / 4 h / 20 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 4 h / 20 °C

3.2: 16 h / 0 - 20 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With pyridine; di-isopropyl azodicarboxylate; boron tribromide; p-toluenesulfonyl chloride; triphenylphosphine; In tetrahydrofuran; dichloromethane; 4.1: Mitsunobu reaction;

DOI:10.1039/c2ob00022a

upstream raw materials:

1-bromo-4-methoxy-benzene

2-methoxyacridine-9-carboxylic acid

C₉H₉ClO₂

C₂₅H₂₁NO₅

Downstream raw materials:

C₂HF₃O₂*C₃₉H₅₂N₄O₁₀S₂

C₄₈H₆₁N₅O₁₅S₂

C₂₉H₂₉NO₈S