tert-butyl 7-hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylate

Base Information

• Chemical Name: tert-butyl 7-hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylate
• CAS No.: 1453315-70-2
• Molecular Formula: C₁₁H₁₉NO₃S
• Molecular Weight: 245.343
• Hs Code.: 2934999090
• Mol file: 1453315-70-2.mol

Synonyms:tert-butyl 7-hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylate

Chemical Property of tert-butyl 7-hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylate

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

TERT-BUTYL-7-HYDROXY-5-THIA-2-AZASPIRO[3.4]OCTANE-2-CARBOXYLATE 95.00% ^*data from reagent suppliers

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Technology Process of tert-butyl 7-hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylate

There total 2 articles about tert-butyl 7-hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C11H17NO3S (1453315-68-8) → tert-butyl 7-hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylate (1453315-70-2)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol402127b

Reference yield:

tert-butyl 3-oxoazetidine-1-carboxylate (398489-26-4) → tert-butyl 7-hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylate (1453315-70-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane / 6 h / Inert atmosphere; Schlenk technique; Reflux

2.1: 1,2-dimethoxyethane; mineral oil / -10 - 20 °C / Inert atmosphere

2.2: 3 h / 120 °C / Inert atmosphere

3.1: sodium tetrahydroborate / methanol / 2 h / 0 °C / Inert atmosphere

With sodium tetrahydroborate; In methanol; 1,2-dimethoxyethane; dichloromethane; mineral oil; 1.1: |Wittig Olefination / 2.2: |Krapcho Dealkoxycarbonylation;

DOI:10.1021/ol402127b

Reference yield: 89.0%

tert-butyl 7-hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylate (1453315-70-2) → C11H19NO5S (1453315-78-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol402127b

upstream raw materials:

tert-butyl 3-oxoazetidine-1-carboxylate

C₁₁H₁₇NO₃S

Downstream raw materials:

tert-butyl 7-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide

C₁₁H₁₉NO₅S

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