5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(2-fluoro-2-methyl-propyl)-piperidin-4-yl]-furo[2,3-c]pyridine

Base Information

Chemical Name:5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(2-fluoro-2-methyl-propyl)-piperidin-4-yl]-furo[2,3-c]pyridine
CAS No.:1451163-45-3
Molecular Formula:C₂₃H₂₆F₂N₂O₃S
Molecular Weight:448.534
Hs Code.:

Synonyms:5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(2-fluoro-2-methyl-propyl)-piperidin-4-yl]-furo[2,3-c]pyridine

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Chemical Property of 5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(2-fluoro-2-methyl-propyl)-piperidin-4-yl]-furo[2,3-c]pyridine

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Technology Process of 5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(2-fluoro-2-methyl-propyl)-piperidin-4-yl]-furo[2,3-c]pyridine

There total 6 articles about 5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(2-fluoro-2-methyl-propyl)-piperidin-4-yl]-furo[2,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1451163-59-9
1-{4-[5-(2-fluoro-4-methanesulfonyl-phenyl)-furo[2,3-c]pyridin-2-yl]-piperidin-1-yl}-2-methyl-propan-2-ol

: 1451163-45-3
5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(2-fluoro-2-methyl-propyl)-piperidin-4-yl]-furo[2,3-c]pyridine

Guidance literature:: With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; toluene; at 20 ℃; Cooling with ice;

Reference yield:

: 1382136-55-1
4-(5-chloro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester

: 1451163-45-3
5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(2-fluoro-2-methyl-propyl)-piperidin-4-yl]-furo[2,3-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane; methanol / 2 h / Reflux; Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: 0.08 h

3.1: dichloromethane; methanol / 50 °C

4.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; toluene / 20 °C / Cooling with ice

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; trifluoroacetic acid; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In 1,4-dioxane; methanol; dichloromethane; water; toluene;

Reference yield:

: 1382136-84-6
4-[5-(2-fluoro-4-methanesulfonyl-phenyl)-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

: 1451163-45-3
5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(2-fluoro-2-methyl-propyl)-piperidin-4-yl]-furo[2,3-c]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

1.2: 0.08 h

2.1: dichloromethane; methanol / 50 °C

3.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; toluene / 20 °C / Cooling with ice

With trifluoroacetic acid; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In methanol; dichloromethane; toluene;