tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate

Base Information

Chemical Name:tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate
CAS No.:852616-64-9
Molecular Formula:C₂₆H₃₅NO₃Si
Molecular Weight:437.654
Hs Code.:

Synonyms:tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate

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Chemical Property of tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate

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Technology Process of tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate

There total 14 articles about tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: tert-butyl (S)-allyl{1-[(tert-butyldiphenylsilyl)oxy]but-3-en-2-yl}carbamate

: 852616-64-9
tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: With Grubbs catalyst first generation; In dichloromethane; at 20 ℃;
DOI:10.3390/molecules24050873

Reference yield: 94.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 205444-34-4
(S)-tert-butyl 2-(hydroxymethyl)-2,5-dihydro-1H-pyrrole-1-carboxylate

: 852616-64-9
tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 24h;
DOI:10.1016/j.tetasy.2006.12.023

Reference yield:

: 920009-47-8
(2S,3S)-3-(N-allyl-N-tert-butoxycarbonyl)amino-4-pentene-1,2-diol

: 852616-64-9
tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / Grubbs first generation catalyst / CH₂Cl₂ / 4 h / 40 °C

2.1: NaIO₄ / tetrahydrofuran; H₂O / 2 h

2.2: 30 percent / LiBH₄ / methanol; diethyl ether / 4 h

3.1: 94 percent / imidazole / dimethylformamide / 24 h

With 1H-imidazole; sodium periodate; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1.1: olefin metathesis;
DOI:10.1016/j.tetasy.2006.12.023