7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(3-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Base Information

Chemical Name:7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(3-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide
CAS No.:497849-98-6
Molecular Formula:C₃₆H₃₉N₃O₅
Molecular Weight:593.723
Hs Code.:

Synonyms:7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(3-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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Chemical Property of 7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(3-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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Technology Process of 7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(3-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

There total 9 articles about 7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(3-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 497849-97-5
7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(3-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

: 497849-98-6
7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(3-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃;
DOI:10.1248/cpb.52.818

Reference yield:

: 3430-17-9
2-bromo-3-picoline

: 497849-98-6
7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(3-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 77 percent / sodium p-toluenesulfinate; NaH / tetrahydrofuran / 3.5 h / Heating

2.1: 100 percent / K₂CO₃; O₂ / dimethylsulfoxide; H₂O / 144 h / 20 °C

3.1: NaN₃ / dimethylsulfoxide / 21 h / 90 °C

4.1: 2.60 g / LiAlH₄ / tetrahydrofuran / 3 h / 20 °C

5.1: benzotriazol-1-ol; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 1.5 h / 20 °C

5.2: 45 percent / Et₃N / dimethylformamide / 20 °C

6.1: 71 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 20 °C

7.1: 56 percent / NaBH₄ / ethanol / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; oxygen; sodium hydride; potassium carbonate; benzotriazol-1-ol; sodium 4-methylbenzenesulfinate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.52.818

Reference yield:

: 459-22-3
4-fluorophenylacetonitrile

: 497849-98-6
7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(3-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 77 percent / sodium p-toluenesulfinate; NaH / tetrahydrofuran / 3.5 h / Heating

2.1: 100 percent / K₂CO₃; O₂ / dimethylsulfoxide; H₂O / 144 h / 20 °C

3.1: NaN₃ / dimethylsulfoxide / 21 h / 90 °C

4.1: 2.60 g / LiAlH₄ / tetrahydrofuran / 3 h / 20 °C

5.1: benzotriazol-1-ol; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 1.5 h / 20 °C

5.2: 45 percent / Et₃N / dimethylformamide / 20 °C

6.1: 71 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 20 °C

7.1: 56 percent / NaBH₄ / ethanol / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; oxygen; sodium hydride; potassium carbonate; benzotriazol-1-ol; sodium 4-methylbenzenesulfinate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.52.818