3-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-nitro-3-trifluoromethyl-phenyl)-amide

Base Information

• Chemical Name: 3-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-nitro-3-trifluoromethyl-phenyl)-amide
• CAS No.: 888072-23-9
• Molecular Formula: C₁₃H₁₀F₆N₄O₃
• Molecular Weight: 384.238
• Mol file: 888072-23-9.mol

Synonyms:3-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-nitro-3-trifluoromethyl-phenyl)-amide

Chemical Property of 3-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-nitro-3-trifluoromethyl-phenyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-nitro-3-trifluoromethyl-phenyl)-amide

There total 5 articles about 3-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-nitro-3-trifluoromethyl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(1E)-trifluoromethyl-methylidene]toluenesulfonyl-hydrazone (888071-59-8) + 2-methyl-N-<4-nitro-3-(trifluoromethyl)phenyl>-2-propenamide (90357-52-1) → 3-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-nitro-3-trifluoromethyl-phenyl)-amide (888072-23-9) + C13H10F6N4O3

Guidance literature:

2-[(1E)-trifluoromethyl-methylidene]toluenesulfonyl-hydrazone; With sodium hydride; In tetrahydrofuran; at 0 ℃;

2-methyl-N-<4-nitro-3-(trifluoromethyl)phenyl>-2-propenamide; In tetrahydrofuran; at 55 ℃; Further stages.;

DOI:10.1021/jm0613976

Reference yield:

C13H10F6N4O3 → 3-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-nitro-3-trifluoromethyl-phenyl)-amide (888072-23-9)

Guidance literature:

With trifluoroacetic acid; at 20 ℃;

DOI:10.1021/jm0613976

Reference yield:

2-methyl-N-<4-nitro-3-(trifluoromethyl)phenyl>-2-propenamide (90357-52-1) → 3-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-nitro-3-trifluoromethyl-phenyl)-amide (888072-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0 °C

1.2: tetrahydrofuran / 55 °C

2.1: trifluoroacetic acid / 20 °C

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran;

DOI:10.1021/jm0613976

upstream raw materials:

2-methyl-N-<4-nitro-3-(trifluoromethyl)phenyl>-2-propenamide

2-[(1E)-trifluoromethyl-methylidene]toluenesulfonyl-hydrazone

4-nitro-3-(trifluoromethyl)benzeneamine

Downstream raw materials:

3-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-nitro-3-trifluoromethyl-phenyl)-amide