4-{8-[3-cyclopropyl-4-(trifluoromethyl)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate

Base Information

Chemical Name:4-{8-[3-cyclopropyl-4-(trifluoromethyl)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate
CAS No.:1360918-56-4
Molecular Formula:C₂HF₃O₂*C₂₅H₂₅F₃N₂O₄
Molecular Weight:588.504
Hs Code.:

Synonyms:4-{8-[3-cyclopropyl-4-(trifluoromethyl)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate

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Chemical Property of 4-{8-[3-cyclopropyl-4-(trifluoromethyl)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate

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Technology Process of 4-{8-[3-cyclopropyl-4-(trifluoromethyl)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate

There total 1 articles about 4-{8-[3-cyclopropyl-4-(trifluoromethyl)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126689-01-8
cyclopropylboronic acid pinacol ester

: 1360918-58-6
methyl 4-{8-[3-bromo-4-(trifluoromethyl)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoate

: 76-05-1
trifluoroacetic acid

: 1360918-56-4
4-{8-[3-cyclopropyl-4-(trifluoromethyl)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate

Guidance literature:: cyclopropylboronic acid pinacol ester; methyl 4-{8-[3-bromo-4-(trifluoromethyl)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoate; With lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 120 ℃; for 0.5h; Microwave irradiation;

trifluoroacetic acid; In water; acetonitrile;