C₆₂H₆₅ClFNO₁₉

Base Information

• Chemical Name: C₆₂H₆₅ClFNO₁₉
• CAS No.: 152932-87-1
• Molecular Formula: C₆₂H₆₅ClFNO₁₉
• Molecular Weight: 1182.64
• Mol file: 152932-87-1.mol

Synonyms:C₆₂H₆₅ClFNO₁₉

Chemical Property of C₆₂H₆₅ClFNO₁₉

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₂H₆₅ClFNO₁₉

There total 5 articles about C₆₂H₆₅ClFNO₁₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,4-tri-O-benzyl-L-fucopyranosyl fluoride (127061-08-9) → C62H65ClFNO19 (152932-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / AgClO₄, SnCl₂, 4A-molecular sieves / diethyl ether; tetrahydrofuran / 1 h / -10 - 0 °C

2: 80 percent / DAST, NBS / CH₂Cl₂ / 2 h / -78 - -20 °C

With N-Bromosuccinimide; 4 A molecular sieve; silver perchlorate; 4,4'-diaminostilbene-2,2'-disulfonic acid; tin(ll) chloride; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/ja00072a049

Reference yield:

Chloro-acetic acid (2R,3S,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-fluoro-tetrahydro-pyran-4-yl ester → C62H65ClFNO19 (152932-87-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 63 percent / AgOTf, Cp₂HfCl₂, 2,6-di-tert-butyl-4-methylpyridine, 4A-molecular sieves / CH₂Cl₂ / 6 h / 0 - 25 °C

2: 76 percent / NaCNBH₃, HCl, 3A-molecular sieves / diethyl ether; tetrahydrofuran / 0.5 h / 0 °C

3: 95 percent / AgClO₄, SnCl₂, 4A-molecular sieves / diethyl ether; tetrahydrofuran / 1 h / -10 - 0 °C

4: 80 percent / DAST, NBS / CH₂Cl₂ / 2 h / -78 - -20 °C

With hydrogenchloride; N-Bromosuccinimide; 2,6-di-tert-butyl-4-methylpyridine; bis(cyclopentadienyl)hafnium dichloride; 3 A molecular sieve; 4 A molecular sieve; silver trifluoromethanesulfonate; silver perchlorate; sodium cyanoborohydride; 4,4'-diaminostilbene-2,2'-disulfonic acid; tin(ll) chloride; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/ja00072a049

Reference yield:

phenyl 4,6-di-O-benzylidene-2-deoxy-2-phthalimido-1-thio-β-D-glucopyranoside (127061-09-0) → C62H65ClFNO19 (152932-87-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 63 percent / AgOTf, Cp₂HfCl₂, 2,6-di-tert-butyl-4-methylpyridine, 4A-molecular sieves / CH₂Cl₂ / 6 h / 0 - 25 °C

2: 76 percent / NaCNBH₃, HCl, 3A-molecular sieves / diethyl ether; tetrahydrofuran / 0.5 h / 0 °C

3: 95 percent / AgClO₄, SnCl₂, 4A-molecular sieves / diethyl ether; tetrahydrofuran / 1 h / -10 - 0 °C

4: 80 percent / DAST, NBS / CH₂Cl₂ / 2 h / -78 - -20 °C

With hydrogenchloride; N-Bromosuccinimide; 2,6-di-tert-butyl-4-methylpyridine; bis(cyclopentadienyl)hafnium dichloride; 3 A molecular sieve; 4 A molecular sieve; silver trifluoromethanesulfonate; silver perchlorate; sodium cyanoborohydride; 4,4'-diaminostilbene-2,2'-disulfonic acid; tin(ll) chloride; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/ja00072a049

upstream raw materials:

2,3,4-tri-O-benzyl-L-fucopyranosyl fluoride

phenyl 4,6-di-O-benzylidene-2-deoxy-2-phthalimido-1-thio-β-D-glucopyranoside

Chloro-acetic acid (2R,3S,4S,5R,6R)-3,5-diacetoxy-2-acetoxymethyl-6-[(2R,3S,4R,5R,6S)-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-6-phenylsulfanyl-tetrahydro-pyran-4-yloxy]-tetrahydro-pyran-4-yl ester

Chloro-acetic acid (2R,3S,4S,5R,6R)-3,5-diacetoxy-2-acetoxymethyl-6-[(2R,4aR,6S,7R,8R,8aS)-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-6-phenylsulfanyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-tetrahydro-pyran-4-yl ester

Downstream raw materials:

C₆₇H₇₁NO₂₂S

C₆₇H₇₁NO₁₉

C₅₅H₆₅NO₁₈S

C₆₉H₇₂ClNO₂₀