Technology Process of tert-butyl-((R)-4-(naphthalen-2-ylmethoxy)methyl-3-(((2R,3R)-3-(trityloxymethyl)oxiran-2-yl)methyl)butoxy)diphenylsilane
There total 12 articles about tert-butyl-((R)-4-(naphthalen-2-ylmethoxy)methyl-3-(((2R,3R)-3-(trityloxymethyl)oxiran-2-yl)methyl)butoxy)diphenylsilane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Shi's ketone; oxone||potassium monopersulfate triple salt; tetra(n-butyl)ammonium hydrogensulfate; edetate disodium; potassium carbonate; acetic acid; potassium hydroxide;
In
water; acetonitrile;
at 20 ℃;
for 9h;
stereoselective reaction;
DOI:10.3762/bjoc.9.132
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
2: sodium iodide / acetone / 18 h / Darkness; Reflux; Inert atmosphere
3: lithium chloride; lithium diisopropyl amide / tetrahydrofuran
4: lithium amidotrihydridoborate / tetrahydrofuran / 0 - 20 °C
5: sodium hydride; tetra-(n-butyl)ammonium iodide; 1H-imidazole / tetrahydrofuran / 0 °C
6: Shi's ketone; oxone||potassium monopersulfate triple salt; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; potassium hydroxide; acetic acid; edetate disodium / acetonitrile; water / 9 h / 20 °C
With
1H-imidazole; Shi's ketone; lithium amidotrihydridoborate; oxone||potassium monopersulfate triple salt; tetra(n-butyl)ammonium hydrogensulfate; edetate disodium; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; acetic acid; triethylamine; sodium iodide; lithium chloride; potassium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; water; acetone; acetonitrile;
3: |Myers's Alkylation / 6: |Shi Asymmetric Epoxidation;
DOI:10.3762/bjoc.9.132
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium iodide / acetone / 18 h / Darkness; Reflux; Inert atmosphere
2: lithium chloride; lithium diisopropyl amide / tetrahydrofuran
3: lithium amidotrihydridoborate / tetrahydrofuran / 0 - 20 °C
4: sodium hydride; tetra-(n-butyl)ammonium iodide; 1H-imidazole / tetrahydrofuran / 0 °C
5: Shi's ketone; oxone||potassium monopersulfate triple salt; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; potassium hydroxide; acetic acid; edetate disodium / acetonitrile; water / 9 h / 20 °C
With
1H-imidazole; Shi's ketone; lithium amidotrihydridoborate; oxone||potassium monopersulfate triple salt; tetra(n-butyl)ammonium hydrogensulfate; edetate disodium; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; acetic acid; sodium iodide; lithium chloride; potassium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; water; acetone; acetonitrile;
2: |Myers's Alkylation / 5: |Shi Asymmetric Epoxidation;
DOI:10.3762/bjoc.9.132
