2β-(1-propanoyl)-3β-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane

Base Information

Chemical Name:2β-(1-propanoyl)-3β-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane
CAS No.:306740-55-6
Molecular Formula:C₁₇H₂₁Cl₂NO
Molecular Weight:326.266
Hs Code.:

Synonyms:2β-(1-propanoyl)-3β-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane

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Chemical Property of 2β-(1-propanoyl)-3β-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane

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Technology Process of 2β-(1-propanoyl)-3β-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane

There total 7 articles about 2β-(1-propanoyl)-3β-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 306740-54-5
2β-carboxylic acid methoxymethylamide-3β-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane

: 306740-55-6
2β-(1-propanoyl)-3β-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 - 22 ℃; for 4h;
DOI:10.1021/jm0301484

Reference yield:

: 143965-99-5
dicholoropane

: 306740-55-6
2β-(1-propanoyl)-3β-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 2 steps

1.1: Al(CH₃)3 / CH₂Cl₂; hexane / -10 - 22 °C

1.2: 88 percent / CH₂Cl₂; hexane / 24 h / 22 °C

2.1: 71 percent / tetrahydrofuran; diethyl ether / 4 h / 0 - 22 °C

With trimethylaluminum; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jm0301484

Reference yield:

: 85506-18-9
(1R)-(-)-2-carbomethoxy-3-tropinone

: 306740-55-6
2β-(1-propanoyl)-3β-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium bistrimethylsilylamide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 97 percent / tetrahydrofuran / -78 - 22 °C

2.1: 83 percent / LiCl; aq. Na₂CO₃; Pd₂dba3 / various solvent(s) / 3 h / Heating

3.1: SmI₂ / tetrahydrofuran / 0.75 h / -78 °C

3.2: 26 percent / MeOH / tetrahydrofuran / 2 h

4.1: Al(CH₃)3 / CH₂Cl₂; hexane / -10 - 22 °C

4.2: 88 percent / CH₂Cl₂; hexane / 24 h / 22 °C

5.1: 71 percent / tetrahydrofuran; diethyl ether / 4 h / 0 - 22 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; samarium diiodide; trimethylaluminum; sodium hexamethyldisilazane; sodium carbonate; lithium chloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 2.1: Suzuki coupling;
DOI:10.1021/jm0301484