(3S,4R)-3-<<(2-Nitrophenyl)sulfenyl>amino>-4-benzyl-2-oxetanone

Base Information

• Chemical Name: (3S,4R)-3-<<(2-Nitrophenyl)sulfenyl>amino>-4-benzyl-2-oxetanone
• CAS No.: 157457-76-6
• Molecular Formula: C₁₆H₁₄N₂O₄S
• Molecular Weight: 330.364
• Mol file: 157457-76-6.mol

Synonyms:(3S,4R)-3-<<(2-Nitrophenyl)sulfenyl>amino>-4-benzyl-2-oxetanone

Chemical Property of (3S,4R)-3-<<(2-Nitrophenyl)sulfenyl>amino>-4-benzyl-2-oxetanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,4R)-3-<<(2-Nitrophenyl)sulfenyl>amino>-4-benzyl-2-oxetanone

There total 3 articles about (3S,4R)-3-<<(2-Nitrophenyl)sulfenyl>amino>-4-benzyl-2-oxetanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

(2S,3R)-2-<<(2-Nitrophenyl)sulfenyl>amino>-3-hydroxy-4-phenylbutanoic acid (157457-73-3) → (3S,4R)-3-<<(2-Nitrophenyl)sulfenyl>amino>-4-benzyl-2-oxetanone (157457-76-6)

Guidance literature:

With pyridine; 4-bromobenzenesulfonyl chloride; 1.) -45 deg C, 1 h, 2.) 0 deg C, 4 h;

DOI:10.1021/jo00092a025

Reference yield:

phenylacetaldehyde (122-78-1) → (3S,4R)-3-<<(2-Nitrophenyl)sulfenyl>amino>-4-benzyl-2-oxetanone (157457-76-6)

Guidance literature:

Multi-step reaction with 3 steps

2: 83 percent / 1N aq. NaOH / dioxane / 0.33 h

3: 41 percent / 4-BrC₆H₄SO₂Cl, pyridine / 1.) -45 deg C, 1 h, 2.) 0 deg C, 4 h

With pyridine; sodium hydroxide; 4-bromobenzenesulfonyl chloride; In 1,4-dioxane;

DOI:10.1021/jo00092a025

Reference yield:

(2S,3R)-2-Amino-3-hydroxy-4-phenylbutanoic acid (157543-53-8) → (3S,4R)-3-<<(2-Nitrophenyl)sulfenyl>amino>-4-benzyl-2-oxetanone (157457-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / 1N aq. NaOH / dioxane / 0.33 h

2: 41 percent / 4-BrC₆H₄SO₂Cl, pyridine / 1.) -45 deg C, 1 h, 2.) 0 deg C, 4 h

With pyridine; sodium hydroxide; 4-bromobenzenesulfonyl chloride; In 1,4-dioxane;

DOI:10.1021/jo00092a025

upstream raw materials:

(2S,3R)-2-<<(2-Nitrophenyl)sulfenyl>amino>-3-hydroxy-4-phenylbutanoic acid

phenylacetaldehyde

(2S,3R)-2-Amino-3-hydroxy-4-phenylbutanoic acid