N₄-(2'-fluorophenyl)-N₂-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride

Base Information

Chemical Name:N₄-(2'-fluorophenyl)-N₂-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride
CAS No.:1395885-27-4
Molecular Formula:C₁₇H₁₃FN₄O₂*ClH
Molecular Weight:360.775
Hs Code.:

N<sub>4</sub>-(2'-fluorophenyl)-N<sub>2</sub>-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride

Synonyms:N₄-(2'-fluorophenyl)-N₂-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N₄-(2'-fluorophenyl)-N₂-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride

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Technology Process of N₄-(2'-fluorophenyl)-N₂-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride

There total 2 articles about N₄-(2'-fluorophenyl)-N₂-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 616229-75-5
N⁴-(2-fluorophenyl)-2-chloropyrimidine-4-amine

: 1395885-27-4
N₄-(2'-fluorophenyl)-N₂-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride

Guidance literature:: In ethanol; at 150 ℃; for 0.333333h; Microwave irradiation;
DOI:10.1021/jm300334d

Reference yield:

: 348-54-9
2-Fluoroaniline

: 1395885-27-4
N₄-(2'-fluorophenyl)-N₂-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 20 h / 125 °C / Sealed tube

2: ethanol / 0.33 h / 150 °C / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; In ethanol; butan-1-ol;
DOI:10.1021/jm300334d