(R)-6-chloro-N-(5-(4-(2-(methyl(prop-2-ynyl)amino)propyl)phenoxy)pentyl)-1,2,3,4-tetrahydroacridin-9-amine

Base Information

Chemical Name:(R)-6-chloro-N-(5-(4-(2-(methyl(prop-2-ynyl)amino)propyl)phenoxy)pentyl)-1,2,3,4-tetrahydroacridin-9-amine
CAS No.:1430326-23-0
Molecular Formula:C₃₁H₃₈ClN₃O
Molecular Weight:504.115
Hs Code.:

Synonyms:(R)-6-chloro-N-(5-(4-(2-(methyl(prop-2-ynyl)amino)propyl)phenoxy)pentyl)-1,2,3,4-tetrahydroacridin-9-amine

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Chemical Property of (R)-6-chloro-N-(5-(4-(2-(methyl(prop-2-ynyl)amino)propyl)phenoxy)pentyl)-1,2,3,4-tetrahydroacridin-9-amine

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Technology Process of (R)-6-chloro-N-(5-(4-(2-(methyl(prop-2-ynyl)amino)propyl)phenoxy)pentyl)-1,2,3,4-tetrahydroacridin-9-amine

There total 8 articles about (R)-6-chloro-N-(5-(4-(2-(methyl(prop-2-ynyl)amino)propyl)phenoxy)pentyl)-1,2,3,4-tetrahydroacridin-9-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.5%

: 1430326-09-2
(R)-N-(1-(4-(5-bromopentyloxy)phenyl)propan-2-yl)-N-methylprop-2-yn-1-amine

: 5778-84-7
6-chlorotacrine

: 1430326-23-0
(R)-6-chloro-N-(5-(4-(2-(methyl(prop-2-ynyl)amino)propyl)phenoxy)pentyl)-1,2,3,4-tetrahydroacridin-9-amine

Guidance literature:: 6-chlorotacrine; With potassium hydroxide; In dimethyl sulfoxide; for 0.333333h;

(R)-N-(1-(4-(5-bromopentyloxy)phenyl)propan-2-yl)-N-methylprop-2-yn-1-amine; In dimethyl sulfoxide; for 24h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.01.039

Reference yield:

: [2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-amine

: 1430326-23-0
(R)-6-chloro-N-(5-(4-(2-(methyl(prop-2-ynyl)amino)propyl)phenoxy)pentyl)-1,2,3,4-tetrahydroacridin-9-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: L-Tartaric acid / ethanol

2.1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 40 °C / 1.5?MPa

3.1: potassium carbonate / toluene; acetonitrile / 16 h / 20 °C / Inert atmosphere

4.1: formic acid / 12 h / 90 °C

5.1: boron tribromide / dichloromethane / -20 - 20 °C / Inert atmosphere

6.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / Inert atmosphere; Reflux

7.1: potassium hydroxide / dimethyl sulfoxide / 0.33 h

7.2: 24 h / Inert atmosphere

With formic acid; L-Tartaric acid; palladium 10% on activated carbon; hydrogen; boron tribromide; potassium carbonate; potassium iodide; potassium hydroxide; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1016/j.ejmech.2013.01.039

Reference yield:

: 1430326-04-7
(R)-N-(1-(4-methoxyphenyl)propan-2-yl)prop-2-yn-1-amine

: 1430326-23-0
(R)-6-chloro-N-(5-(4-(2-(methyl(prop-2-ynyl)amino)propyl)phenoxy)pentyl)-1,2,3,4-tetrahydroacridin-9-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: formic acid / 12 h / 90 °C

2.1: boron tribromide / dichloromethane / -20 - 20 °C / Inert atmosphere

3.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / Inert atmosphere; Reflux

4.1: potassium hydroxide / dimethyl sulfoxide / 0.33 h

4.2: 24 h / Inert atmosphere

With formic acid; boron tribromide; potassium carbonate; potassium iodide; potassium hydroxide; In dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.ejmech.2013.01.039