benzyl 4-oxo-4-[5'-aminosulfamoyl-5'-deoxy-2',3'-O-isopropylidene-adenosine]-butyrate

Base Information

• Chemical Name: benzyl 4-oxo-4-[5'-aminosulfamoyl-5'-deoxy-2',3'-O-isopropylidene-adenosine]-butyrate
• CAS No.: 548483-90-5
• Molecular Formula: C₂₄H₂₈N₆O₉S
• Molecular Weight: 576.587
• Mol file: 548483-90-5.mol

Synonyms:benzyl 4-oxo-4-[5'-aminosulfamoyl-5'-deoxy-2',3'-O-isopropylidene-adenosine]-butyrate

Chemical Property of benzyl 4-oxo-4-[5'-aminosulfamoyl-5'-deoxy-2',3'-O-isopropylidene-adenosine]-butyrate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of benzyl 4-oxo-4-[5'-aminosulfamoyl-5'-deoxy-2',3'-O-isopropylidene-adenosine]-butyrate

There total 1 articles about benzyl 4-oxo-4-[5'-aminosulfamoyl-5'-deoxy-2',3'-O-isopropylidene-adenosine]-butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

succinic acid monobenzyl ester (103-40-2) + ((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate (112921-00-3) → benzyl 4-oxo-4-[5'-aminosulfamoyl-5'-deoxy-2',3'-O-isopropylidene-adenosine]-butyrate (548483-90-5)

Guidance literature:

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 0 - 20 ℃;

DOI:10.1021/ol034212n

Reference yield: 89.0%

benzyl 4-oxo-4-[5'-aminosulfamoyl-5'-deoxy-2',3'-O-isopropylidene-adenosine]-butyrate (548483-90-5) → benzyl 4-oxo-4-[5'-aminosulfamoyl-5'-deoxyadenosine]-butyrate

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 3h;

DOI:10.1021/ol034212n

upstream raw materials:

succinic acid monobenzyl ester

((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate