4-nitro-5-phenylthio-2-phenylthiomethoxyphenol

Base Information

• Chemical Name: 4-nitro-5-phenylthio-2-phenylthiomethoxyphenol
• CAS No.: 158719-71-2
• Molecular Formula: C₁₉H₁₅NO₄S₂
• Molecular Weight: 385.464
• Mol file: 158719-71-2.mol

Synonyms:4-nitro-5-phenylthio-2-phenylthiomethoxyphenol

Chemical Property of 4-nitro-5-phenylthio-2-phenylthiomethoxyphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitro-5-phenylthio-2-phenylthiomethoxyphenol

There total 1 articles about 4-nitro-5-phenylthio-2-phenylthiomethoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.2%

1-bromo-4,5-methylenedioxy-2-nitrobenzene (7748-58-5) + thiophenol (108-98-5) → 5-Nitro-6-phenylsulfanyl-benzo[1,3]dioxole + 4-nitro-5-phenylthio-2-phenylthiomethoxyphenol (158719-71-2)

Guidance literature:

With sodium methylate; In dimethyl sulfoxide; at 130 ℃; for 0.166667h;

DOI:10.1248/cpb.42.500

Reference yield:

4-nitro-5-phenylthio-2-phenylthiomethoxyphenol (158719-71-2) → 4-Amino-5-phenylsulfanyl-2-phenylsulfanylmethoxy-phenol (1027545-05-6)

Guidance literature:

With sodium tetrahydroborate; nickel dichloride; In methanol; benzene; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.42.500

Reference yield:

4-nitro-5-phenylthio-2-phenylthiomethoxyphenol (158719-71-2) → N-(6-Phenylsulfanyl-benzo[1,3]dioxol-5-yl)-acetamide

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄, NiCl₂ x 6 H₂₀ / benzene; methanol / 0.5 h / Ambient temperature

2: pyridine / 1 h / Ambient temperature

3: anh. K₂CO₃, Cu, CuBr / nitrobenzene / 5 h / Heating

With pyridine; sodium tetrahydroborate; copper; potassium carbonate; copper(I) bromide; nickel dichloride; In methanol; nitrobenzene; benzene;

DOI:10.1248/cpb.42.500

upstream raw materials:

1-bromo-4,5-methylenedioxy-2-nitrobenzene

thiophenol

Downstream raw materials:

4-Amino-5-phenylsulfanyl-2-phenylsulfanylmethoxy-phenol

Acetic acid 4-acetylamino-5-phenylsulfanyl-2-phenylsulfanylmethoxy-phenyl ester

Refernces