8-(4-(trifluoromethoxy)phenyl)-3,4-dihydro-1H-thiopyrano[4,3-b]quinilin-10(5H)-one

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Chemical Name:8-(4-(trifluoromethoxy)phenyl)-3,4-dihydro-1H-thiopyrano[4,3-b]quinilin-10(5H)-one
CAS No.:1312077-78-3
Molecular Formula:C₁₉H₁₄F₃NO₂S
Molecular Weight:377.387
Hs Code.:

Synonyms:8-(4-(trifluoromethoxy)phenyl)-3,4-dihydro-1H-thiopyrano[4,3-b]quinilin-10(5H)-one

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Chemical Property of 8-(4-(trifluoromethoxy)phenyl)-3,4-dihydro-1H-thiopyrano[4,3-b]quinilin-10(5H)-one

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Technology Process of 8-(4-(trifluoromethoxy)phenyl)-3,4-dihydro-1H-thiopyrano[4,3-b]quinilin-10(5H)-one

There total 4 articles about 8-(4-(trifluoromethoxy)phenyl)-3,4-dihydro-1H-thiopyrano[4,3-b]quinilin-10(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1312077-70-5
8-bromo-3,4-dihydro-1H-thiopyrano[4,3-b]quinolin-10(5H)-one

: 139301-27-2
4-trifluoromethoxyphenylboronic acid

: 1312077-78-3
8-(4-(trifluoromethoxy)phenyl)-3,4-dihydro-1H-thiopyrano[4,3-b]quinilin-10(5H)-one

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; In water; N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;
DOI:10.1021/jm200015a

Reference yield:

: 673-79-0
diethyl 3,3'-thiobispropionate

: 1312077-78-3
8-(4-(trifluoromethoxy)phenyl)-3,4-dihydro-1H-thiopyrano[4,3-b]quinilin-10(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol; sodium hydride / diethyl ether / 8 h / Reflux

2.1: acetic acid / benzene / 100 °C

2.2: Reflux

3.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate / water; N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; sodium hydride; sodium carbonate; acetic acid; In diethyl ether; water; N,N-dimethyl-formamide; benzene; 2.1: Conrad-Limpach synthesis / 2.2: Conrad-Limpach synthesis / 3.1: Suzuki coupling;
DOI:10.1021/jm200015a

Reference yield:

: 1198-44-3
ethyl 4-oxotetrahydro-2H-thiopyran-3-carboxylate

: 1312077-78-3
8-(4-(trifluoromethoxy)phenyl)-3,4-dihydro-1H-thiopyrano[4,3-b]quinilin-10(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / benzene / 100 °C

1.2: Reflux

2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate / water; N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; acetic acid; In water; N,N-dimethyl-formamide; benzene; 1.1: Conrad-Limpach synthesis / 1.2: Conrad-Limpach synthesis / 2.1: Suzuki coupling;
DOI:10.1021/jm200015a