C₃₉H₆₇NO₄SSiSn

Base Information

• Chemical Name: C₃₉H₆₇NO₄SSiSn
• CAS No.: 1195973-76-2
• Molecular Formula: C₃₉H₆₇NO₄SSiSn
• Molecular Weight: 792.827
• Mol file: 1195973-76-2.mol

Synonyms:C₃₉H₆₇NO₄SSiSn

Chemical Property of C₃₉H₆₇NO₄SSiSn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₉H₆₇NO₄SSiSn

There total 9 articles about C₃₉H₆₇NO₄SSiSn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

(6S,7S)-9-(tert-Butyl-dimethyl-silanyloxy)-8-methyl-7-prop-1-ynyl-2-(toluene-4-sulfonyl)-2-aza-spiro[5.5]undec-8-en-1-one (870290-88-3) → C27H41NO4SSi + C39H67NO4SSiSn (1195973-76-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; tri-n-butyl-tin hydride; In tetrahydrofuran; hexanes; Inert atmosphere;

DOI:10.1021/ja207385y

Reference yield:

(6S,7S)-9-(tert-Butyl-dimethyl-silanyloxy)-8-methyl-7-prop-1-ynyl-2-aza-spiro[5.5]undec-8-en-1-one (870290-81-6) → C39H67NO4SSiSn (1195973-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.33 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C / Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride; tri-n-butyl-tin hydride / tetrahydrofuran; hexanes / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; tri-n-butyl-tin hydride; potassium hexamethylsilazane; In tetrahydrofuran; hexanes; toluene;

DOI:10.1021/ja207385y

Reference yield:

Tributyl-((E)-1-methyl-pent-1-en-3-ynyl)-stannane → C39H67NO4SSiSn (1195973-76-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.33 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.17 h / -78 °C / Inert atmosphere

3.1: silver hexafluoroantimonate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; copper dichloride / dichloromethane / 20 °C / Inert atmosphere; Darkness

4.1: n-butyllithium / tetrahydrofuran; hexanes / -78 °C / Inert atmosphere

5.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.33 h / -78 °C / Inert atmosphere

5.2: 2 h / -78 - 20 °C / Inert atmosphere

6.1: bis-triphenylphosphine-palladium(II) chloride; tri-n-butyl-tin hydride / tetrahydrofuran; hexanes / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; silver hexafluoroantimonate; n-butyllithium; tri-n-butyl-tin hydride; potassium hexamethylsilazane; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; triethylamine; copper dichloride; In tetrahydrofuran; hexanes; dichloromethane; toluene; 3.1: Diels-Alder reaction;

DOI:10.1021/ja207385y

upstream raw materials:

(6S,7S)-9-(tert-Butyl-dimethyl-silanyloxy)-8-methyl-7-prop-1-ynyl-2-aza-spiro[5.5]undec-8-en-1-one

(6S,7S)-9-(tert-Butyl-dimethyl-silanyloxy)-8-methyl-1-oxo-7-prop-1-ynyl-2-aza-spiro[5.5]undec-8-ene-2-carboxylic acid benzyl ester

(6S,7S)-9-(tert-Butyl-dimethyl-silanyloxy)-8-methyl-7-prop-1-ynyl-2-(toluene-4-sulfonyl)-2-aza-spiro[5.5]undec-8-en-1-one

3-methylidene-2-oxo-piperidine