biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester oxalate isopropanol salt

Base Information

Chemical Name:biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester oxalate isopropanol salt
CAS No.:1370019-90-1
Molecular Formula:C₂H₂O₄*C₃H₈O*C₄₅H₅₂N₆O₇
Molecular Weight:939.075
Hs Code.:

biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester oxalate isopropanol salt

Synonyms:biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester oxalate isopropanol salt

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Chemical Property of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester oxalate isopropanol salt

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Technology Process of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester oxalate isopropanol salt

There total 16 articles about biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester oxalate isopropanol salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370019-86-5
biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester oxalate salt

: 67-63-0,8013-70-5
isopropyl alcohol

: 1370019-90-1
biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester oxalate isopropanol salt

Guidance literature:: In water; at 20 ℃; for 72h;

Reference yield:

: 2403-53-4
2-(4-nitrophenyl)-1,3-dioxolane

: 1370019-90-1
biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester oxalate isopropanol salt

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogen; sodium hydrogencarbonate / platinum(IV) oxide / ethanol / 2.25 h / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

3: hydrogenchloride; water / acetonitrile / 2 h / 50 °C

4: sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C

5: triethylamine tris(hydrogen fluoride) / dichloromethane; N,N-dimethyl-formamide / 20 °C

6: ammonium hydroxide / dichloromethane; methanol

7: methanol / 20 - 30 °C / Sonication

8: water / 72 h / 20 °C

With hydrogenchloride; ammonium hydroxide; sodium tris(acetoxy)borohydride; water; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine tris(hydrogen fluoride); 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 1370019-90-1
biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester oxalate isopropanol salt

Guidance literature:: Multi-step reaction with 9 steps

1: toluene-4-sulfonic acid / toluene / 4 h / 120 °C

2: hydrogen; sodium hydrogencarbonate / platinum(IV) oxide / ethanol / 2.25 h / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

4: hydrogenchloride; water / acetonitrile / 2 h / 50 °C

5: sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C

6: triethylamine tris(hydrogen fluoride) / dichloromethane; N,N-dimethyl-formamide / 20 °C

7: ammonium hydroxide / dichloromethane; methanol

8: methanol / 20 - 30 °C / Sonication

9: water / 72 h / 20 °C

With hydrogenchloride; ammonium hydroxide; sodium tris(acetoxy)borohydride; water; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; triethylamine tris(hydrogen fluoride); 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;