3-[2-bromo-5-[3-(dimethylamino)propoxy]phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Base Information

Chemical Name:3-[2-bromo-5-[3-(dimethylamino)propoxy]phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
CAS No.:634604-85-6
Molecular Formula:C₂₃H₂₂BrN₃O₃
Molecular Weight:468.35
Hs Code.:

Synonyms:3-[2-bromo-5-[3-(dimethylamino)propoxy]phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

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Chemical Property of 3-[2-bromo-5-[3-(dimethylamino)propoxy]phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

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Technology Process of 3-[2-bromo-5-[3-(dimethylamino)propoxy]phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

There total 5 articles about 3-[2-bromo-5-[3-(dimethylamino)propoxy]phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 634605-43-9
C₁₃H₁₉BrN₂O₂

: 18372-22-0
2-(3-indolyl)oxoacetic acid methyl ester

: 634604-85-6
3-[2-bromo-5-[3-(dimethylamino)propoxy]phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield:

: 1477-49-2
3-indolylglyoxylic acid

: 634604-85-6
3-[2-bromo-5-[3-(dimethylamino)propoxy]phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; hexane; dichloromethane / 0 - 20 °C

2: sodium hydride / tetrahydrofuran / 5 h / 20 °C

With sodium hydride; In tetrahydrofuran; methanol; hexane; dichloromethane;

Reference yield:

: 51506-70-8
(2-bromo-5-hydroxy-phenyl)-acetonitrile

: 634604-85-6
3-[2-bromo-5-[3-(dimethylamino)propoxy]phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 3 h / 60 °C

2: potassium hydroxide; tert-butyl alcohol / 0.75 h / Heating / reflux

3: sodium hydride / tetrahydrofuran / 5 h / 20 °C

With potassium hydroxide; sodium hydride; potassium carbonate; tert-butyl alcohol; In tetrahydrofuran; DMF (N,N-dimethyl-formamide);