2-[(2-chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine

Base Information

Chemical Name:2-[(2-chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine
CAS No.:71621-39-1
Molecular Formula:C₁₈H₂₀ClNO₃
Molecular Weight:333.815
Hs Code.:

Synonyms:2-[(2-chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine

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Chemical Property of 2-[(2-chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine

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Technology Process of 2-[(2-chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine

There total 10 articles about 2-[(2-chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-[1-(2-Chloro-phenyl)-1-(2-methoxy-phenoxy)-ethyl]-morpholin-3-one

: 71621-39-1
2-[(2-chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; for 20h; Yield given; Ambient temperature;

Reference yield:

: 90-05-1
2-methoxy-phenol

: 71621-39-1
2-[(2-chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) NaH / 1.) dimethylacetamide, 1-1.5 h, 40 deg C; 2.) dimethylacetamide, 5 h, 90 deg C

2: KOH / methanol / 20 h / Ambient temperature

3: SOCl₂ / 16 h / Ambient temperature

4: LiAlH(O-tBu)3 / bis-(2-methoxy-ethyl) ether / 0.5 h / -60 °C

5: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux

6: LiAlH₄ / diethyl ether; tetrahydrofuran / also with BH₃; 1.) 16 h, RT; 2.) 1 h, 40 deg C

7: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C

8: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

9: sodium bis(2-methoxy-ethoxy)aluminium hydride / toluene / 20 h / Ambient temperature

With potassium cyanide; sodium metabisulfite; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; potassium tert-butylate; sodium hydride; lithium tri-t-butoxyaluminum hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; diethylene glycol dimethyl ether; toluene; tert-butyl alcohol;

Reference yield:

: (2-Chloro-phenyl)-(2-methoxy-phenoxy)-acetaldehyde

: 71621-39-1
2-[(2-chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux

2: LiAlH₄ / diethyl ether; tetrahydrofuran / also with BH₃; 1.) 16 h, RT; 2.) 1 h, 40 deg C

3: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C

4: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

5: sodium bis(2-methoxy-ethoxy)aluminium hydride / toluene / 20 h / Ambient temperature

With potassium cyanide; sodium metabisulfite; lithium aluminium tetrahydride; potassium tert-butylate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; tert-butyl alcohol;