-6-(1H-indol-3-ylmethyl)-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazadecanoic acid

Base Information

Chemical Name:-6-(1H-indol-3-ylmethyl)-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazadecanoic acid
CAS No.:144876-75-5
Molecular Formula:C₃₀H₃₁N₅O₆
Molecular Weight:557.606
Hs Code.:

<R-(R*,R*)>-6-(1H-indol-3-ylmethyl)-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazadecanoic acid

Synonyms:-6-(1H-indol-3-ylmethyl)-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazadecanoic acid

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Chemical Property of -6-(1H-indol-3-ylmethyl)-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazadecanoic acid

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Technology Process of -6-(1H-indol-3-ylmethyl)-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazadecanoic acid

There total 5 articles about -6-(1H-indol-3-ylmethyl)-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazadecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 144876-69-7
methyl -6-(1H-indol-3-ylmethyl)-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazatetradecanoate

: 144876-75-5
-6-(1H-indol-3-ylmethyl)-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazadecanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 25 ℃;
DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

: 130406-36-9,142854-51-1
((S)-2-Amino-1-phenyl-ethyl)-carbamic acid benzyl ester

: 144876-75-5
-6-(1H-indol-3-ylmethyl)-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazadecanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1) hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / 1) THF, EtOAc, 25 deg C, 2 h, 2) 25 deg C, 17 h

2: 89 percent / piperidine / dimethylformamide / 17 h / 0 °C

3: 83 percent / toluene; tetrahydrofuran / 16 h / 80 - 100 °C

4: 95 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 25 °C

With piperidine; lithium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

: 35737-15-6,144701-22-4,86123-11-7
N-(9-fluorenylmethoxycarbonyl)-D-tryptophan

: 144876-75-5
-6-(1H-indol-3-ylmethyl)-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazadecanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1) hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / 1) THF, EtOAc, 25 deg C, 2 h, 2) 25 deg C, 17 h

2: 89 percent / piperidine / dimethylformamide / 17 h / 0 °C

3: 83 percent / toluene; tetrahydrofuran / 16 h / 80 - 100 °C

4: 95 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 25 °C

With piperidine; lithium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)86596-0