(4R)-<<5-(Tetrahydropyran-2-yloxy)-4-methyl-1-pentyl>oxy>(1,1-dimethylethyl)diphenylsilane

Base Information

Chemical Name:(4R)-<<5-(Tetrahydropyran-2-yloxy)-4-methyl-1-pentyl>oxy>(1,1-dimethylethyl)diphenylsilane
CAS No.:165961-48-8
Molecular Formula:C₂₇H₄₀O₃Si
Molecular Weight:440.698
Hs Code.:

Synonyms:(4R)-<<5-(Tetrahydropyran-2-yloxy)-4-methyl-1-pentyl>oxy>(1,1-dimethylethyl)diphenylsilane

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Chemical Property of (4R)-<<5-(Tetrahydropyran-2-yloxy)-4-methyl-1-pentyl>oxy>(1,1-dimethylethyl)diphenylsilane

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Technology Process of (4R)-<<5-(Tetrahydropyran-2-yloxy)-4-methyl-1-pentyl>oxy>(1,1-dimethylethyl)diphenylsilane

There total 7 articles about (4R)-<<5-(Tetrahydropyran-2-yloxy)-4-methyl-1-pentyl>oxy>(1,1-dimethylethyl)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 152033-12-0
(4R)-5-(Tetrahydropyran-2-yloxy)-4-methyl-1-pentanol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 165961-48-8
(4R)-<<5-(Tetrahydropyran-2-yloxy)-4-methyl-1-pentyl>oxy>(1,1-dimethylethyl)diphenylsilane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74091-3

Reference yield:

: Ethyl (4R)-5-(tetrahydropyran-2-yloxy)-4-methyl-2-pentenoate

: 165961-48-8
(4R)-<<5-(Tetrahydropyran-2-yloxy)-4-methyl-1-pentyl>oxy>(1,1-dimethylethyl)diphenylsilane

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethyl acetate / 6 h / 25 °C

2: LiAlH₄ / diethyl ether / 0.5 h / 25 °C

3: 99 percent / imidazole / dimethylformamide / 18 h / 25 °C

With 1H-imidazole; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00121a026

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 165961-48-8
(4R)-<<5-(Tetrahydropyran-2-yloxy)-4-methyl-1-pentyl>oxy>(1,1-dimethylethyl)diphenylsilane

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / p-TsOH / diethyl ether

2: 87 percent / LiAlH₄ / diethyl ether / 3 °C

3: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -78 deg C

4: NaH / tetrahydrofuran / -78 °C

5: hydrogen / Pd-C / ethanol

6: LiAlH₄ / diethyl ether / 3 °C

7: 99 percent / imidazole / dimethylformamide

With 1H-imidazole; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74091-3