1-methyl-2-<<<2(S)-amino-3-(1H-indol-3-yl)propanoyl>amino>methyl>-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine dihydrochloride

Base Information

Chemical Name:1-methyl-2-<<<2(S)-amino-3-(1H-indol-3-yl)propanoyl>amino>methyl>-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine dihydrochloride
CAS No.:102428-94-4
Molecular Formula:C₂₈H₂₈FN₅O*2ClH
Molecular Weight:542.484
Hs Code.:

Synonyms:1-methyl-2-<<<2(S)-amino-3-(1H-indol-3-yl)propanoyl>amino>methyl>-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine dihydrochloride

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Chemical Property of 1-methyl-2-<<<2(S)-amino-3-(1H-indol-3-yl)propanoyl>amino>methyl>-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine dihydrochloride

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Technology Process of 1-methyl-2-<<<2(S)-amino-3-(1H-indol-3-yl)propanoyl>amino>methyl>-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine dihydrochloride

There total 2 articles about 1-methyl-2-<<<2(S)-amino-3-(1H-indol-3-yl)propanoyl>amino>methyl>-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 102428-92-2
[(S)-1-{[5-(2-Fluoro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-ylmethyl]-carbamoyl}-2-(1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester

: 102428-94-4
1-methyl-2-<<<2(S)-amino-3-(1H-indol-3-yl)propanoyl>amino>methyl>-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine dihydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate;
DOI:10.1021/jm00163a069

Reference yield:

: 83737-97-7
1-methyl-2-(aminomethyl)-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine

: 102428-94-4
1-methyl-2-<<<2(S)-amino-3-(1H-indol-3-yl)propanoyl>amino>methyl>-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine dihydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, triethylamine / CH₂Cl₂ / 10 h / pH 8

2: 99 percent / hydrogen chloride / ethyl acetate

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00163a069