5-HYDROXY-2-OXO-2,3-DIHYDRO-1H-[1]BENZAZEPHE-4-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 5-HYDROXY-2-OXO-2,3-DIHYDRO-1H-[1]BENZAZEPHE-4-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 108993-98-2
• Molecular Formula: C₁₃H₁₃NO₄
• Molecular Weight: 247.251
• Hs Code.: 2933990090
• Mol file: 108993-98-2.mol

Synonyms:2,3-Dihydro-5-hydroxy-2-oxo-1H-1-benzazepine-4-carboxylicacid ethyl ester

Chemical Property of 5-HYDROXY-2-OXO-2,3-DIHYDRO-1H-[1]BENZAZEPHE-4-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Melting Point: 197-200°C
• Boiling Point: 482.7±45.0 °C(Predicted)
• PKA: 4.50±1.00(Predicted)
• PSA: 75.63000
• Density: 1.322±0.06 g/cm3(Predicted)
• LogP: 1.99900
• Storage Temp.: -20°C Freezer

Purity/Quality:

97% ^*data from raw suppliers

5-Hydroxy-2-oxo-2,3-dihydro-1H-[1]benzazephe-4-carboxylic Acid Ethyl Ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-HYDROXY-2-OXO-2,3-DIHYDRO-1H-[1]BENZAZEPHE-4-CARBOXYLIC ACID ETHYL ESTER

There total 7 articles about 5-HYDROXY-2-OXO-2,3-DIHYDRO-1H-[1]BENZAZEPHE-4-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 2,3,-Dihydro-5-hydroxy-2-oxo-1H-1-benzazepin-4-carbonsaeureethylester (108993-98-2)

Guidance literature:

Reference yield: 29.5%

2-ethoxycarbonylaniline (87-25-2) + succinic acid diethyl ester (123-25-1) → 2,3,-Dihydro-5-hydroxy-2-oxo-1H-1-benzazepin-4-carbonsaeureethylester (108993-98-2)

Guidance literature:

2-ethoxycarbonylaniline; succinic acid diethyl ester; With sodium hydride; In toluene; Heating / reflux;

With hydrogenchloride; water; In toluene;

Reference yield:

diethyl ester of succinoylanthranilic acid (120572-43-2) → 2,3,-Dihydro-5-hydroxy-2-oxo-1H-1-benzazepin-4-carbonsaeureethylester (108993-98-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; dimethylsulfoxide-d6; at 20 ℃;

DOI:10.1016/S0968-0896(02)00616-8

upstream raw materials:

diethyl ester of succinoylanthranilic acid

ethyl 3-(chloroformyl)propionate

2-ethoxycarbonylaniline

succinic acid diethyl ester

Downstream raw materials:

2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol

5-hydroxy-1-phenylcarbamoyl-2,3,4,5-tetrahydro-1H-1-benzazepine

(1-{[methyl-(4-nitro-benzyl)-carbamoyl]-methyl}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-acetic acid tert-butyl ester

{1-[3-(4-nitro-phenyl)-isoxazol-5-ylmethyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl}-acetic acid tert-butyl ester

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