1-(4-amino-3-hydroxy-phenyl)-3-[4-(4-fluorobenzyl)piperidin-1-yl]propan-1-one

Base Information

Chemical Name:1-(4-amino-3-hydroxy-phenyl)-3-[4-(4-fluorobenzyl)piperidin-1-yl]propan-1-one
CAS No.:746666-22-8
Molecular Formula:C₂₁H₂₅FN₂O₂
Molecular Weight:356.44
Hs Code.:

Synonyms:1-(4-amino-3-hydroxy-phenyl)-3-[4-(4-fluorobenzyl)piperidin-1-yl]propan-1-one

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Chemical Property of 1-(4-amino-3-hydroxy-phenyl)-3-[4-(4-fluorobenzyl)piperidin-1-yl]propan-1-one

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Technology Process of 1-(4-amino-3-hydroxy-phenyl)-3-[4-(4-fluorobenzyl)piperidin-1-yl]propan-1-one

There total 4 articles about 1-(4-amino-3-hydroxy-phenyl)-3-[4-(4-fluorobenzyl)piperidin-1-yl]propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 746666-23-9
(4-[3-[4-(4-fluorobenzyl)piperidino]propionyl]-2-hydroxy-phenyl)-carbamic acid tert-butyl ester

: 746666-22-8
1-(4-amino-3-hydroxy-phenyl)-3-[4-(4-fluorobenzyl)piperidin-1-yl]propan-1-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 4.5h;
DOI:10.1016/j.bmc.2004.03.065

Reference yield:

: 178165-43-0
EMD 95885

: 746666-22-8
1-(4-amino-3-hydroxy-phenyl)-3-[4-(4-fluorobenzyl)piperidin-1-yl]propan-1-one

Guidance literature:: EMD 95885; With dmap; di-tert-butyl dicarbonate; triethylamine; In tetrahydrofuran;

With trifluoroacetic acid; In dichloromethane;

Reference yield:

: 59-49-4
2-Benzoxazolinone

: 746666-22-8
1-(4-amino-3-hydroxy-phenyl)-3-[4-(4-fluorobenzyl)piperidin-1-yl]propan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 29 percent / AlCl₃ / dimethylformamide / 2 h / 75 °C

2.1: 71 percent / Et₃N / ethanol / 2 h / 20 °C

3.1: Et₃N; DMAP / tetrahydrofuran / 2 h / 20 °C

3.2: 89 percent / K₂CO₃ / methanol / 1.5 h / 20 °C

4.1: 80 percent / trifluoroacetic acid / CH₂Cl₂ / 4.5 h / 0 - 20 °C

With dmap; aluminium trichloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.03.065