1-cyano-2,2-dimethyl-3-(2-methylpropenyl)-1-(phenylsulfonyl)cyclopropane

Base Information

Chemical Name:1-cyano-2,2-dimethyl-3-(2-methylpropenyl)-1-(phenylsulfonyl)cyclopropane
CAS No.:77081-19-7
Molecular Formula:C₁₆H₁₉NO₂S
Molecular Weight:289.398
Hs Code.:

Synonyms:1-cyano-2,2-dimethyl-3-(2-methylpropenyl)-1-(phenylsulfonyl)cyclopropane

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Chemical Property of 1-cyano-2,2-dimethyl-3-(2-methylpropenyl)-1-(phenylsulfonyl)cyclopropane

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Technology Process of 1-cyano-2,2-dimethyl-3-(2-methylpropenyl)-1-(phenylsulfonyl)cyclopropane

There total 4 articles about 1-cyano-2,2-dimethyl-3-(2-methylpropenyl)-1-(phenylsulfonyl)cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 77097-75-7
Acetic acid (E)-5-benzenesulfonyl-5-cyano-1,1,4,4-tetramethyl-pent-2-enyl ester

: 77081-19-7
1-cyano-2,2-dimethyl-3-(2-methylpropenyl)-1-(phenylsulfonyl)cyclopropane

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 65 ℃; for 3h;
DOI:10.1021/jo00324a049

Reference yield:

: 77081-09-5
(E)-6-hydroxy-2-(phenylsulfonyl)-3,3,6-trimethyl-4-heptenenitrile

: 77081-19-7
1-cyano-2,2-dimethyl-3-(2-methylpropenyl)-1-(phenylsulfonyl)cyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / NEt₃, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) 0 deg C, 5 h, 2.) 25 deg C, 2 h

2: 80 percent / NaH / tetrahydrofuran / 3 h / 65 °C

With dmap; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00324a049

Reference yield:

: 75646-37-6
Acetic acid (Z)-4-hydroxy-1,1,4-trimethyl-pent-2-enyl ester

: 77081-19-7
1-cyano-2,2-dimethyl-3-(2-methylpropenyl)-1-(phenylsulfonyl)cyclopropane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH, 2.) (PPh₃)4Pd / 1.) THF, 2.) DME, 65-70 deg C, 15 h

2: 85 percent / NEt₃, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) 0 deg C, 5 h, 2.) 25 deg C, 2 h

3: 80 percent / NaH / tetrahydrofuran / 3 h / 65 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00324a049